지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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This study was performed to investigate the effect of dietary protein level throughout gestation and lactation on milk composition and on postnatal growth in infants, using rats as an animal model. Female Sprague-Dawley rats were provided with either high(25% ISP(Isolated 50y Protein)diet) or low protein diet(10% ISP diet) throughout gestation and lactation. Milk samples were taken for analysis from the lactating rats at days of 7, 14, 21, of lactation. Dams and some pups were killed after 4 weeks from parturition (Experiment 1). Pups from dams of each diet groups were randomly selected and reared with 25% or 10% ISP diet for 4 more weeks (Experiment 2). In experiment 1, maternal protein intake and body weight gain throughout gestation and lactation was higher in 25% ISP group. Serum protein, Ca, Fe, Zn, K concentrations were significantly higher in 25% ISP group. There was no difference in birth weight between two groups, however the mean body weight at 4 weeks postpartum was significantly higher in 25% ISP group.
Serum profiles of pups at weaning were similar to that of dams. Milk compositions were changed during lactation processes and were affected by dietary protein level. Lactose and Ca, Cu, Fe concentrations in milk were higher in 25% ISP group, whereas， lipid，triglyceride were higher in 10% ISP group. In experiment 2, food intake was higher in pups from dams of 25% ISP group but was unaffected by pup's dietary protein level after weaning. The weights of liver and kidney were affected by maternal protein intake. The weight of intestine was affected by both maternal protein intake and pup’s diet. The weights of femur and scapula were affected by maternal protein intake. There were no differences between four groups in serum profiles. Therefore，as mentioned above， it seemed that the effect of maternal protein malnutrition to fetus was able to be overcome to some extent by high protein diet intake after weaning. In conclusion, 1) Dietary protein level throughout gestation and lactation affected both nutritional status of dams and pups and milk composition: 25% ISP group supported better nutritional status than 10% ISP group. 2) 1t seemed that effect of dietary protein leve1 after weaning on pups was able to be overcome the influence of maternal diet in fetus to some extent. (Korean J Nutrition 32(8) : 855-863, 1999)
Serum profiles of pups at weaning were similar to that of dams. Milk compositions were changed during lactation processes and were affected by dietary protein level. Lactose and Ca, Cu, Fe concentrations in milk were higher in 25% ISP group, whereas， lipid，triglyceride were higher in 10% ISP group. In experiment 2, food intake was higher in pups from dams of 25% ISP group but was unaffected by pup's dietary protein level after weaning. The weights of liver and kidney were affected by maternal protein intake. The weight of intestine was affected by both maternal protein intake and pup’s diet. The weights of femur and scapula were affected by maternal protein intake. There were no differences between four groups in serum profiles. Therefore，as mentioned above， it seemed that the effect of maternal protein malnutrition to fetus was able to be overcome to some extent by high protein diet intake after weaning. In conclusion, 1) Dietary protein level throughout gestation and lactation affected both nutritional status of dams and pups and milk composition: 25% ISP group supported better nutritional status than 10% ISP group. 2) 1t seemed that effect of dietary protein leve1 after weaning on pups was able to be overcome the influence of maternal diet in fetus to some extent. (Korean J Nutrition 32(8) : 855-863, 1999)
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UCI(KEPA) : I410-ECN-0101-2012-594-004459270