지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 1,521 - 1,529 (9page)
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초록· 키워드
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We determined acute endurance exercise on mTOR signaling responses in aging skeletal muscle(soleus; SOL, extensor digitorium longus; EDL). Total 32 Sprague-Dawley rats were divided into two groups by age; young group(YG; 20wk; n=16) or old group(OG; 72wk; n=16). Each experimental group was further allocated two subgroups; Exercise(EX; n=8), Control(CON; n=8) group. All animals in exercise group performed one bout of 3hr endurance swimming exercise (30min×6bouts). The phosphorylation of mammalian target of rapamycin(mTOR) and p70 ribosomal S6 kinase(p70S6K) were significantly increased in 20wk(YG) soleus (p＜.05). However, the phosphorylation of mTOR and eukaryotic initiation of factor 4E binding protein 1(4EBP1) were significantly decreased in 72wk(OG) muscles(p＜.05) after endurance acute swimming exercise. The phosphorylation state of AMPK was significantly increased in 20wk(YG) muscles(p＜.05) and 72wk soleus(p＜.01) after exercise.
The results suggest that a bout endurance exercise was increased AMPK activity but inhibited mTOR and 4E-BP1 phosphorylation in aging slow-twitch muscle.
The results suggest that a bout endurance exercise was increased AMPK activity but inhibited mTOR and 4E-BP1 phosphorylation in aging slow-twitch muscle.
목차
Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과 및 논의
Ⅳ. 결론
참고문헌
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Baldwin, K, M. / 1982 / Biochemical properties of overloaded fast-twitch skeletal muscle / J Appl Physiol 52 : 467 ~ 472
2. [학술지(정기간행물)] - Beugnet A / 2003 / Target of rapamycin(TOR) -signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1 / J Biol Chem 278 : 40717 ~ 40722
3. [학술지(정기간행물)] - Bodine, S, C. / 2001 / Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo / Nat Cell Biol 3 (11) : 1014 ~ 1019
4. [학술지(정기간행물)] - Camera D, M. / 2010 / Early time course of Akt phosphorylation after endurance and resistance exercise.Med Sci Sports Exerc.42(10) / Med Sci Sports Exerc 42 (10) : 1843 ~ 1852
5. [학술지(정기간행물)] - Chan, A, Y. / 2005 / Activation of AMP-activated protein kinase (AMPK) inhibits protein synthesis: a potential strategy to prevent the development of cardiac hypertrophy / Can J Physiol Pharmacol 83 (1) : 24 ~ 28
2. [학술지(정기간행물)] - Beugnet A / 2003 / Target of rapamycin(TOR) -signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1 / J Biol Chem 278 : 40717 ~ 40722
3. [학술지(정기간행물)] - Bodine, S, C. / 2001 / Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo / Nat Cell Biol 3 (11) : 1014 ~ 1019
4. [학술지(정기간행물)] - Camera D, M. / 2010 / Early time course of Akt phosphorylation after endurance and resistance exercise.Med Sci Sports Exerc.42(10) / Med Sci Sports Exerc 42 (10) : 1843 ~ 1852
5. [학술지(정기간행물)] - Chan, A, Y. / 2005 / Activation of AMP-activated protein kinase (AMPK) inhibits protein synthesis: a potential strategy to prevent the development of cardiac hypertrophy / Can J Physiol Pharmacol 83 (1) : 24 ~ 28
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UCI(KEPA) : I410-ECN-0101-2013-692-000489651