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초록· 키워드
The hypoglycemic effect of Polygonatum odoratum var. Pluriflorum Ohwi was investigated after extracted with methanol. The methanol extract was fractionated into 4 layers ; hexane, chloroform, butanol and aqueous. Fifty male Sprague-Dawley rats(200 - 300g) were induced diabetes mellitus by the streptozotocin injection(45mg/kg B.W.) into the tail vein and were divided into 5 groups ; diabetic control and 4 experimental groups. All groups of the rats were fed on a AIN-76 diet, and the 4 experimental groups were orally administered with each fraction(500mg/kg B.W.) for 12 days and the diabetic control group was orally administered CMC. The body weight gain was monitored and the blood levels of glucose and cholesterol were measured. Levels of protein, triglyceride, and free fatty acid in plasma were analysed. The contents of protein, triglyceride and glycogen in liver and of protein and glycogen in muscle were also determined. The body weight gain was shown significantly higher in the H₂O fraction group than that in the diabetic control group and the heart weight was greater in the CHCl₃ group. The extents of blood glucose decrement were greater in the BuOH and H₂O groups than that in the control group. The urinary glucose excretion was shown relatively small amount in the BuOH and H₂O groups. The plasma cholesterol and protein levels were not influenced by these four fractions in diabetic rats. The liver glycogen level was significantly higher in the BuOH group.
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목차
- ABSTRACT
- 서론
- 재료 및 방법
- 결과 및 고찰
- 결론
- Literature Cited
참고문헌
참고문헌 신청최근 본 자료
UCI(KEPA) : I410-ECN-0101-2013-594-000272724
