지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 181 - 184 (4page)
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초록· 키워드
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Screening of estrogenic activity on dichloro diphenyl trichloroethane (DDT), dichloro diphenyl dichloro ethylene (DDE), dieldrin, heptachlor, aldrin, chlordane, lindane, polybrominated diphenyl ethers (PBDE) and parabens was compared using Organization for Economic Cooperation and Development (OECD) test guideline 455 (TG455). The estrogenic activity of DDT was 58,000-fold (PC??, 1.67 × 10?? M) less than 17β-estradiol(E₂) (PC??, 2.88 × 10?¹¹ M) but DDE, dieldrin, heptachlor, aldrin, chlordane, lindane and PBDE did not show any estrogenic activity in this assay system. In the case of paraben compounds, the rank of relative transcriptional activation (logRTA) was butyl paraben ?1.63752 (PC??, 1.25 × 10??M) ＞ isobutyl paraben ?2.34008 (PC??, 6.3 × 10??M) ＞ ethyl paraben ?2.64016 (PC??, 1.26 × 10?? M) ＞ isopropyl paraben ?2.73993 (PC??, 1.58 × 10??M) ＞ propyl paraben ?2.84164 (PC??, 2.0 × 10?? M). Our data suggest that OECD test guideline TG455 may be useful as a screening tool for potential endocrine disruptors.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (16)
참고문헌 신청
Bonefeld-Jorgensen, E.C / 2003 / Toxicologicalproperties of POPs and related health effects of concern for thearctic populations, in: AMAP assessment 2002: Human Healthin the Arctic
Bonefeld-Jorgensen,E.C / 2004 / The human health effect programmein Greenland, a review / Sci. Total Environ 331:215~231
Colborn, T. / 1993 / Developmentaleffects of endocrine-disrupting chemicals in wildlife andhumans / Environ. Health Perspect 101:378~384
Coldham, N.G. / 1997 / Evaluation of a recombinantyeast cell estrogen screening assay / Environ. Health Perspect 105:734~742
Damdimopoulos, A.E. / 2008 / Ligands Differentially Modify the Nuclear Mobility of EstrogenReceptors alpha and beta / Endocrinology 149:339~345
Bonefeld-Jorgensen,E.C / 2004 / The human health effect programmein Greenland, a review / Sci. Total Environ 331:215~231
Colborn, T. / 1993 / Developmentaleffects of endocrine-disrupting chemicals in wildlife andhumans / Environ. Health Perspect 101:378~384
Coldham, N.G. / 1997 / Evaluation of a recombinantyeast cell estrogen screening assay / Environ. Health Perspect 105:734~742
Damdimopoulos, A.E. / 2008 / Ligands Differentially Modify the Nuclear Mobility of EstrogenReceptors alpha and beta / Endocrinology 149:339~345
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UCI(KEPA) : I410-ECN-0101-2013-513-000310557