지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 185 - 190 (6page)
이용수
초록· 키워드
오류제보하기
Di-(2-ethylhexyl)-phthalate (DEHP), the most widely utilized industrial plastizer and a ubiquitous environmental contaminant, can act on peroxisome proliferators-activated nuclear hormone receptor family (PPAR) isoforms. To understand the contribution of sphingolipid metabolism to DEHP-induced hepatotoxicity, effect of DEHP exposure on activities of sphingolipid metabolic enzymes in rat liver was investigated. DEHP (250, 500 or 750 ㎎/㎏) was administered to the rats through oral gavage daily for 28 days. The activities of acidic and alkaline ceramidases were slightly increased in 250 ㎎/㎏ DEHP-administered rat livers and significantly elevated in 500 ㎎/㎏ DEHP-administered ones, although the level of 750 ㎎/㎏ DEHP-administered ones was not increased. Neutral ceramidase, acidic and neutral sphingomyelinases, sphingomyeline synthase and ceramide syhthase were not changed at all by DEHP exposure. Therefore, acidic and alkaline ceramidases might play important roles in DEHP-induced hepatotoxicity.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENT
REFERENCES
참고문헌 (24)
참고문헌 신청
Adinehzadeh, M / 1998 / Effects of peroxisomeproliferators on rat liver phospholipids: sphingomyelin degradationmay be involved in hepatotoxic mechanism of perfluorodecanoicacid / Chem. Res. Toxicol 11:428~440
Bligh, E.G / 1959 / A rapid method of total lipidextraction and purification / Can. J. Biochem. Physiol 37:911~917
Chalfant, C.E. / 2002 / De novo ceramideregulates the alternative splicing of caspase 9 and Bcl-x inA549 lung adenocarcinoma cells. Dependence on protein phosphatase-1 / J. Biol. Chem 277:12587~12595
Chen, J. / 1995 / Regulation of cytochrome P450 2C11(CYP2C11) gene expression by interleukin-1, sphingomyelinhydrolysis, and ceramides in rat hepatocytes / J. Biol. Chem 270:25233~25238
Chun, Y.J. / 2003 / Activation of Fasreceptor modulates cytochrome P450 3A4 expression in humancolon carcinoma cells / Toxicol. Lett 146:75~81
Bligh, E.G / 1959 / A rapid method of total lipidextraction and purification / Can. J. Biochem. Physiol 37:911~917
Chalfant, C.E. / 2002 / De novo ceramideregulates the alternative splicing of caspase 9 and Bcl-x inA549 lung adenocarcinoma cells. Dependence on protein phosphatase-1 / J. Biol. Chem 277:12587~12595
Chen, J. / 1995 / Regulation of cytochrome P450 2C11(CYP2C11) gene expression by interleukin-1, sphingomyelinhydrolysis, and ceramides in rat hepatocytes / J. Biol. Chem 270:25233~25238
Chun, Y.J. / 2003 / Activation of Fasreceptor modulates cytochrome P450 3A4 expression in humancolon carcinoma cells / Toxicol. Lett 146:75~81
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UCI(KEPA) : I410-ECN-0101-2013-513-000310562