지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.6
- 수록면
- 191 - 195 (5page)
이용수
초록· 키워드
오류제보하기
There is an increasing interest in curcumin (Curcuma longa L.) as a cardiovascular disease (CVD) protective agent via decreased blood total cholesterol and low-density lipoprotein-cholesterol (LDL-cholesterol) level. The aim of this study was to investigate further the potential mechanism in the hypocholesterolemic effect of curcumin by measuring cholesterol 7a-hydroxylase (CYP7A1), a rate limiting enzyme in the biosynthesis of bile acid from cholesterol, at the mRNA level. Male Sprague-Dawley rats were fed a 45% high fat diet or same diet supplemented with curcumin (0.1% wt/wt) for 8 weeks. The curcumin diet significantly decreased serum triglyceride (TG) by 27%, total cholesterol (TC) by 33.8%, and LDL-cholesterol by 56%, respectively as compared to control group. The curcumin-supplemented diet also significantly lowered the atherogenic index (AI) by 48% as compared to control group. Hepatic TG level was significantly reduced by 41% in rats fed with curcumin-supplemented diet in comparison with control group (P＜0.05). Conversely, the curcumin diet significantly increased fecal TG and TC. The curcumin diet up-regulated hepatic CYP7A1 mRNA level by 2.16-fold, compared to control group p (P＜0.05). These findings suggested that the increases in the CYP7A1 gene expression may partially account for the hypocholesterolemic effect of curcumin.
목차
Abstract
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet
Nutrition Research and Practice
2010 .06
-
Estimation of curcumin intake in Korea based on the Korea National Health and Nutrition Examination Survey (2008-2012)
Nutrition Research and Practice
2014 .10
-
Estimation of curcumin intake in Korea based on the Korea National Health and Nutrition Examination Survey (2008-2012)
Nutrition Research and Practice
2014 .10
-
Pretreatment of curcumin protects hippocampal neurons against excitotoxin-induced cell death
생명과학회지
2007 .01
-
Determination of curcumin in rat plasma using UPLC-MS/MS and its application to a pharmacokinetic study of a novel curcumin formulation
한국분석과학회 학술대회
2018 .11
-
Determination of curcumin in rat plasma using UPLC-MS/MS and its application to a pharmacokinetic study of a novel curcumin formulation
한국분석과학회 학술대회
2018 .11
-
Synthesis of Curcumin Glycosides with Enhanced Anticancer Properties Using One-Pot Multienzyme Glycosylation Technique
Journal of Microbiology and Biotechnology
2017 .01
-
Dietary chitosan enhances hepatic CYP7A1 activity and reduces plasma and liver cholesterol concentrations in diet-induced hypercholesterolemia in rats
Nutrition Research and Practice
2007 .09
-
Dietary chitosan enhances hepatic CYP7A1 activity and reduces plasma and liver cholesterol concentrations in diet-induced hypercholesterolemia in rats
Nutrition Research and Practice
2007 .09
-
C57BL/6 마우스에서 고지방 식이와 CCl4로 유발한 간섬유증에 미치는 커큐민의 보호효과
대한임상검사과학회지
2015 .01
-
콜레스테롤 식이를 섭취한 흰쥐에 새송이버섯이 지질대사 및 효소활성에 미치는 영향
생명과학회지
2006 .12
-
식이 Cholesterol의 수준에 따라 우유가 흰쥐의 Cholesterol대사에 미치는 영향
한국영양학회지
1994 .03
-
Curcumin이 인체대장암세포주인 SW480 cell에서 세포사멸에 미치는 영향
한국영양학회지
2004 .01
-
신령버섯 균사체 액체배양액이 고콜레스테롤혈증 흰쥐의 지질대사에 미치는 영향
생명과학회지
2004 .08
-
운지버섯 배양액이 콜레스테롤 식이를 섭취한 흰쥐의 지질 대사에 미치는 영향
생명과학회지
2005 .10
-
Curcumin utilizes the anti-inflammatory response pathway to protect the intestine against bacterial invasion
Nutrition Research and Practice
2015 .04
-
Curcumin utilizes the anti-inflammatory response pathway to protect the intestine against bacterial invasion
Nutrition Research and Practice
2015 .04
-
Curcumin inhibits cellular condensation and alters microfilament organization during chondrogenic differentiation of limb bud mesenchymal cells
Experimental and Molecular Medicine
2009 .01
-
Hypocholesterolemic metabolism of dietary red pericarp glutinous rice rich in phenolic compounds in mice fed a high cholesterol diet
Nutrition Research and Practice
2014 .12
-
Hypocholesterolemic metabolism of dietary red pericarp glutinous rice rich in phenolic compounds in mice fed a high cholesterol diet
Nutrition Research and Practice
2014 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2013-594-000351760