인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Exercise is considered to improve motor function and emotional benefits in patients with Parkinson’s disease. However, it is not clear if clinical improvements are due to neuronal alterations within the affected nigrostriatal region or a result from a more general effect of exercise on affect and motivation.
In previous study, we found that treadmill exercise down regulate the alpha-synuclein in the brain of mouse model of Parkinson’s disease. But still we don’t know about the interaction effect between dopaminergic medicine(L-Dopa) and exercise. The purpose of this study was to determined the effects of treadmill exercise and dopaminergic medicine(L-Dopa) on nigrostriatal neurodegeneration in MPTP induced mouse model of Parkinson Disease.
The results of this study were summarized as follows:
(1) Treadmill exercise decreased synphilin expression levels in substantia nigra and striatum of MPTP-induced parkinson’s disease model.
(2) Treadmill exercise inhibits decrease of cell numbers in substantia nigra and striatum.
(3) Treadmill exercise group’s p-JNK expression level is more lower than sedentary group in subtantia nigra. This means exercise inhibits apoptosis in the brain and induce the cell survival in the brain.
(4) Treadmill exercise increase GDNF expression levels in dentate gyrus rather than sedentary group.
(5) Treadmill exercise increase GDNF expression levels in hippocampus rather than sedentary group. This result(increase of GDNF expression in hippocampus and dentate gyrus) means treadmill exercise profitable for the memory and learning problem also disorientation. The results of this study suggest that treadmill exercise partially prevented dopaminergic neurodegeneration in the nigrostriatal region of the Parkinson’s Disease model, and this effects were may offer a potential therapeutic adjunct to current Parkinson’s Disease therapies in the future.
In previous study, we found that treadmill exercise down regulate the alpha-synuclein in the brain of mouse model of Parkinson’s disease. But still we don’t know about the interaction effect between dopaminergic medicine(L-Dopa) and exercise. The purpose of this study was to determined the effects of treadmill exercise and dopaminergic medicine(L-Dopa) on nigrostriatal neurodegeneration in MPTP induced mouse model of Parkinson Disease.
The results of this study were summarized as follows:
(1) Treadmill exercise decreased synphilin expression levels in substantia nigra and striatum of MPTP-induced parkinson’s disease model.
(2) Treadmill exercise inhibits decrease of cell numbers in substantia nigra and striatum.
(3) Treadmill exercise group’s p-JNK expression level is more lower than sedentary group in subtantia nigra. This means exercise inhibits apoptosis in the brain and induce the cell survival in the brain.
(4) Treadmill exercise increase GDNF expression levels in dentate gyrus rather than sedentary group.
(5) Treadmill exercise increase GDNF expression levels in hippocampus rather than sedentary group. This result(increase of GDNF expression in hippocampus and dentate gyrus) means treadmill exercise profitable for the memory and learning problem also disorientation. The results of this study suggest that treadmill exercise partially prevented dopaminergic neurodegeneration in the nigrostriatal region of the Parkinson’s Disease model, and this effects were may offer a potential therapeutic adjunct to current Parkinson’s Disease therapies in the future.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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UCI(KEPA) : I410-ECN-0101-2013-692-000685353
