지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.8
- 수록면
- 779 - 788 (10page)
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Exercise is considered to improve motor function and emotional benefits in patients with Parkinson’s disease. However, it is not clear if clinical improvements are due to neuronal alterations within the affected nigrostriatal region or a result from a more general effect of exercise on affect and motivation.
In previous study, we found that treadmill exercise down regulate the alpha-synuclein in the brain of mouse model of Parkinson’s disease. But still we don’t know about the interaction effect between dopaminergic medicine(L-Dopa) and exercise. The purpose of this study was to determined the effects of treadmill exercise and dopaminergic medicine(L-Dopa) on nigrostriatal neurodegeneration in MPTP induced mouse model of Parkinson Disease.
The results of this study were summarized as follows:
(1) Treadmill exercise decreased synphilin expression levels in substantia nigra and striatum of MPTP-induced parkinson’s disease model.
(2) Treadmill exercise inhibits decrease of cell numbers in substantia nigra and striatum.
(3) Treadmill exercise group’s p-JNK expression level is more lower than sedentary group in subtantia nigra. This means exercise inhibits apoptosis in the brain and induce the cell survival in the brain.
(4) Treadmill exercise increase GDNF expression levels in dentate gyrus rather than sedentary group.
(5) Treadmill exercise increase GDNF expression levels in hippocampus rather than sedentary group. This result(increase of GDNF expression in hippocampus and dentate gyrus) means treadmill exercise profitable for the memory and learning problem also disorientation. The results of this study suggest that treadmill exercise partially prevented dopaminergic neurodegeneration in the nigrostriatal region of the Parkinson’s Disease model, and this effects were may offer a potential therapeutic adjunct to current Parkinson’s Disease therapies in the future.
In previous study, we found that treadmill exercise down regulate the alpha-synuclein in the brain of mouse model of Parkinson’s disease. But still we don’t know about the interaction effect between dopaminergic medicine(L-Dopa) and exercise. The purpose of this study was to determined the effects of treadmill exercise and dopaminergic medicine(L-Dopa) on nigrostriatal neurodegeneration in MPTP induced mouse model of Parkinson Disease.
The results of this study were summarized as follows:
(1) Treadmill exercise decreased synphilin expression levels in substantia nigra and striatum of MPTP-induced parkinson’s disease model.
(2) Treadmill exercise inhibits decrease of cell numbers in substantia nigra and striatum.
(3) Treadmill exercise group’s p-JNK expression level is more lower than sedentary group in subtantia nigra. This means exercise inhibits apoptosis in the brain and induce the cell survival in the brain.
(4) Treadmill exercise increase GDNF expression levels in dentate gyrus rather than sedentary group.
(5) Treadmill exercise increase GDNF expression levels in hippocampus rather than sedentary group. This result(increase of GDNF expression in hippocampus and dentate gyrus) means treadmill exercise profitable for the memory and learning problem also disorientation. The results of this study suggest that treadmill exercise partially prevented dopaminergic neurodegeneration in the nigrostriatal region of the Parkinson’s Disease model, and this effects were may offer a potential therapeutic adjunct to current Parkinson’s Disease therapies in the future.
목차
Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과 및 논의
Ⅳ. 결론
참고문헌
참고문헌 (14)
참고문헌 신청
1. [학술지(정기간행물)] - Adler CH / 2005 / Nonmotor complications in Parkinson's disease / Mov Disorder 20 (Suppl 11) : S23 ~ S29
2. [학술지(정기간행물)] - Bilowit DS / 1956 / Establishing physical objectives in rehabilitation of patients with Parkinson's disease(gymnasium activities) / Physical Ther Rev 36 : 176 ~ 178
3. [학술지(정기간행물)] - Blum, S. / 2001 / An inhibitory role of the phosphatidylinositol 3-kinase-signaling pathway in vascular endothelial growth factor-induced tissue factor expression / J Biol Chem 276 (36) : 33428 ~ 33434
4. [학술지(정기간행물)] - Brasted PJ / 1999 / Behavioural recovery following striatal transplantation: effects of postoperative training and P-zone volume / Exp Brain Res 128 : 535 ~ 538
5. [학술지(정기간행물)] - Colcher A. / 1999 / Clinical manifestations of Parkinson's disease / Med Clin North Am 83 : 327 ~ 347
2. [학술지(정기간행물)] - Bilowit DS / 1956 / Establishing physical objectives in rehabilitation of patients with Parkinson's disease(gymnasium activities) / Physical Ther Rev 36 : 176 ~ 178
3. [학술지(정기간행물)] - Blum, S. / 2001 / An inhibitory role of the phosphatidylinositol 3-kinase-signaling pathway in vascular endothelial growth factor-induced tissue factor expression / J Biol Chem 276 (36) : 33428 ~ 33434
4. [학술지(정기간행물)] - Brasted PJ / 1999 / Behavioural recovery following striatal transplantation: effects of postoperative training and P-zone volume / Exp Brain Res 128 : 535 ~ 538
5. [학술지(정기간행물)] - Colcher A. / 1999 / Clinical manifestations of Parkinson's disease / Med Clin North Am 83 : 327 ~ 347
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UCI(KEPA) : I410-ECN-0101-2013-692-000685353