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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 339 - 343 (5page)
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Polycyclic aromatic hydrocarbons (PAHs) are well known environmental carcinogens. PAH metabolites, especially BaP-7,8-dihydrodiol, 9,10 epoxide, initiate carcinogenesis via high specificity binding to DNA to form DNA adducts. The Korean red ginseng (KRG) from Panax ginseng has been suggested to protect against damages due to PAH exposure but the mechanism is unknown. Therefore, we investigated effects of KRG on PAH exposure using toxicokinetic methods and changes of PAH-induced oxidative damage during a 2 week-clinical trial (n=21 healthy young female, 23.71±2.43 years). To analyze antioxidative effects of KRG, we measured changes in the levels of urinary malondialdehyde (MDA) before and after KRG treatment. We observed a significant positive association between levels of urinary MDA and 1-hydroxypyrene, a biomarker of PAH exposures (slope=1.47, p=0.03) and confirmed oxidative stress induced by PAH exposures. A reverse significant correlation between KRG treatment and level of urinary MDA was observed (p=0.03). In summary, results of our clinical trial study suggest that KRG plays a significant role in antioxidative as well as toxicokinetic pathways against PAHs exposure.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (17)
참고문헌 신청
1. [단행본] - IARC Working Group on the Evaluation of Carcinogenic Risks to Humans / 2010 / Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures / IARC Press
2. [학술지(정기간행물)] - / 2003 / Sources of Polycyclic Aromatic Hydrocarbon Exposure in Non-Occupationally Exposed Koreans / Environmental and Molecular Mutagenesis 42 (4) : 250 ~ 257
3. [단행본] - Sabo-Attwood T / 2006 / Environmental carcinogens, in Oncology: an evidence-based approach / Springer : 233 ~ 243
4. [학술지(정기간행물)] - / 200306 / Genetic effects on urinary 1-hydroxypyrene levels in a Korean population / Carcinogenesis 24 (6) : 1085 ~ 1089
5. [학술지(정기간행물)] - Shukla R / 2009 / Role of Panax ginseng as an antioxidant after cadmium-induced hepatic injuries / Food Chem Toxicol 47 : 769 ~ 773
2. [학술지(정기간행물)] - / 2003 / Sources of Polycyclic Aromatic Hydrocarbon Exposure in Non-Occupationally Exposed Koreans / Environmental and Molecular Mutagenesis 42 (4) : 250 ~ 257
3. [단행본] - Sabo-Attwood T / 2006 / Environmental carcinogens, in Oncology: an evidence-based approach / Springer : 233 ~ 243
4. [학술지(정기간행물)] - / 200306 / Genetic effects on urinary 1-hydroxypyrene levels in a Korean population / Carcinogenesis 24 (6) : 1085 ~ 1089
5. [학술지(정기간행물)] - Shukla R / 2009 / Role of Panax ginseng as an antioxidant after cadmium-induced hepatic injuries / Food Chem Toxicol 47 : 769 ~ 773
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UCI(KEPA) : I410-ECN-0101-2013-524-000762263