지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 261 - 267 (7page)
이용수
초록· 키워드
오류제보하기
Artemisia iwayomogi, a member of the Compositae, is a perennial herb easily found in Korea and used as a traditional medicine to treat liver disease. AIP1, a water-soluble carbohydrate fraction from Artemisia iwayomogi, showed anti-tumor and immuno-modulating activities in animal studies. A subacute toxicological evaluation of AIP1 was performed for 4 weeks in ICR mice. After administration of AIP1 (0, 20, 100, 500 mg/kg/day), the clinical signs, mortalities, body weight changes, hematology, blood clinical biochemistry, urinalysis, organ histopathology, organ weights and gross finding were examined. The results showed that there were no significant differences in body weight changes, food intakes, water consumptions, or organ weights among different dose groups. Also we observed no death and abnormal clinical signs during the experimental period. Between the groups orally treated with AIP1 and the control group, there was no statistical significance in hematological test or serum biochemical values. Histopathological examination showed no abnormal changes in AIP1 groups. These results suggest that no observed adverse effect level (NOAEL) of the oral administration of AIP1 for 4 weeks was considered to be more than 500 mg/kg/day in mice under the condition investigated in current study.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (13)
참고문헌 신청
HannaAhn / 2003 / Inhibitors of Inducible Nitric Oxide Synthesis Expression from Artemisia iwayomogi / Archives of Pharmacal Research 26(4):301~305
박주흥 / 200505 / AIP1, a water-soluble fraction from Artemisia iwayomogi, suppresses thymocyte apoptosis in vitro and down-regulates the expression of fas gene / BIOLOGICAL & PHARMACEUTICAL BULLETIN 28:921~924
Ji, H.J / 2005 / Acarbohydrate fraction, AIP1, from Artemisia iwayomogi downregulatesFas gene expression and suppresses apoptotic death ofthe thymocytes induced by 2,3,7,8-tectrachlorodibenzo-pdioxin / Biotechnol. Lett 27:253~257
Kang, R.L. / 1993 / The polysaccharide fractions ofArtemisia species / Kor. J. Pharmacon 24:289~295
Kim, A.R. / 2004 / Active components from Artemisia iwayomogi displayingONOO(-) scavenging activity / Phytother. Res 18:1~7
박주흥 / 200505 / AIP1, a water-soluble fraction from Artemisia iwayomogi, suppresses thymocyte apoptosis in vitro and down-regulates the expression of fas gene / BIOLOGICAL & PHARMACEUTICAL BULLETIN 28:921~924
Ji, H.J / 2005 / Acarbohydrate fraction, AIP1, from Artemisia iwayomogi downregulatesFas gene expression and suppresses apoptotic death ofthe thymocytes induced by 2,3,7,8-tectrachlorodibenzo-pdioxin / Biotechnol. Lett 27:253~257
Kang, R.L. / 1993 / The polysaccharide fractions ofArtemisia species / Kor. J. Pharmacon 24:289~295
Kim, A.R. / 2004 / Active components from Artemisia iwayomogi displayingONOO(-) scavenging activity / Phytother. Res 18:1~7
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UCI(KEPA) : I410-ECN-0101-2013-513-001112940