지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 153 - 163 (11page)
이용수
초록· 키워드
오류제보하기
Recent advances in research on depression have confirmed that it is common, chronic, recurrent and disabling mental disorder. The treatment of depression has gained growing importance because of its major impact on the patient’s wellbeing, personal and social achievements. Recently, as an increasing number of antidepressants of various types continue to be developed for the treatment of depression, psychopharmacotherpy is the major approach to depression in clinical setting. Unfortunately, there are clear limitations to the currently approved pharmacotherapies of depression, including the fact that they are all essentially monoamine based, have modest efficacy and a relatively slow onset of efficacy, and suffer from significant tolerability issues. Recently, several promising hypotheses of depression and antidepressant action have been formulated. These hypotheses are based on dysregulation of hypothalamic-pituitaryadrenal(HPA) axis, neurotrophic mechanisms, glutamate, neurokinin, phosphodiesterase, cytokines. This article reviews these most promising novel mechanisms that are not represented in compounds currently approved for depression in either the United States or Europe and that may represent the future of the psychopharmacologic treatment of depression.
목차
서론
신경내분비 기전
신경영양성 기전
그 이외의 기전들
결론
참고문헌
참고문헌 (81)
참고문헌 신청
1. [학술지(정기간행물)] - Kessler RC / 2005 / Prevalence,severity,and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication / Arch Gen Psychiatry 62 : 617 ~ 627
2. [학술지(정기간행물)] - Murray CJ / 1996 / Evidence-based health policy--lessons from the Global Burden of Disease Study / Science 274 : 740 ~ 743
3. [학술지(정기간행물)] - Greenberg PE / 2003 / The economic burden of depression in the United States:how did it change between 1990 and 2000 / J Clin Psychiatry 64 : 1465 ~ 1475
4. [단행본] - World Health Organization / 2001 / The world health report 2001-Mental Health: New understanding / New Hope
5. [학술지(정기간행물)] - Wells KB / 1989 / The functioning and well-being of depressed patients.Results from the Medical Outcomes Study / JAMA 262 : 914 ~ 919
2. [학술지(정기간행물)] - Murray CJ / 1996 / Evidence-based health policy--lessons from the Global Burden of Disease Study / Science 274 : 740 ~ 743
3. [학술지(정기간행물)] - Greenberg PE / 2003 / The economic burden of depression in the United States:how did it change between 1990 and 2000 / J Clin Psychiatry 64 : 1465 ~ 1475
4. [단행본] - World Health Organization / 2001 / The world health report 2001-Mental Health: New understanding / New Hope
5. [학술지(정기간행물)] - Wells KB / 1989 / The functioning and well-being of depressed patients.Results from the Medical Outcomes Study / JAMA 262 : 914 ~ 919
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UCI(KEPA) : I410-ECN-0101-2013-513-001381609