지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 413 - 420 (8page)
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초록· 키워드
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We investigated whether Korean red ginseng (KRG) and highly active antiretroviral therapy (HAART) affect the frequency of gross deletion in 5"LTRIgag in 20 hemophiliacs. This study is a prospective study in 20 hemophiliacs who were infected with Korean subclade B ofHJV-1 from two cash-paid plasma donors in 1990. Over a 13-year period, we obtained 436 amplicons of 5" LTRIgag genes by nested polymerase chain reaction using 147 peripheral blood mononuclear cells. Of the 436 amplicons, 92 (21.1 %) showed gross deletion in 5"LTR/gag. Despite of a 2.3-fold higher monthly dose ofKRG intake, the frequency of gross deletion in 5"LTRlgag (16.4%) was significantly decreased during HAART compared with 28.1% prior to HAART (p<0.01). Gross deletion in 5"LTR/gag was 10% more detected on KRG-therapy than prior to KRG-therapy (p<0.05). In addition, we also obtained 28 amplicons containing premature stop codon or isoleucine at initiation codon of254 amplicons sequenced on KRG intake (7.5%) or HAART (13.6%) compared with 0% before KRG intake. These findings indicate that high frequency of gross deletion in 5"LTRlgag and genetic defects prior to HAART are significantly associated with KRG intake and the detection of gross deletion in 5"LTRIgag is decreased by HAART.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2013-524-001212579