지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 317 - 325 (9page)
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초록· 키워드
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Suaeda asparagoides (Miq.) has long been used as a Korean folk herbal medicine for the treatment of functional gastrointestinal disorders. However, reports on its pharmacological activity on gastrointestinal motility are scarce. The present study investigated the effects of Suaeda asparagoides water fraction of the extract (SAWF) on antral motility in vitro. Muscle strips from rat gastric antrum were set up in an organ bath in a circular orientation. SAWF (100 μg/mL) inhibited the spontaneous contraction of antral circular muscle strips. These inhibitory effects were not significantly affected by tetrodotoxin (1 μM), N<SUP>ω</SUP>-Nitro-Larginine methyl ester hydrochloride (100 μM), 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one (10 μM), ryanodine (10 μM) and phentolamine (10 μM). SAWF-induced inhibition was mostly restored by cyclopiazonic acid (10 μM). Furthermore, the β-adrenergic receptor antagonist, propranolol (10 μM), abolished SAWFinduced inhibition. These results suggest that SAWF may exert its activity on gastrointestinal smooth muscle via a-adrenergic receptors and sarcoplasmic reticulum Ca<SUP>2+</SUP> ATPase.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (32)
참고문헌 신청
Szurszewski JH / 1978 / A study of the canine gastric action potential in the presence of tetraethylammonium chloride / J Physiol 277:91~102
Sanders KM / 2006 / Interstitial cells of cajal as pacemakers in the gastrointestinal tract / Annu Rev Physiol 68:307~343
Bolton TB / 2006 / Calcium events in smooth muscles and their interstitial cells; physiological roles of sparks / J Physiol 570(1):5~11
Karaki H / 1997 / Calcium movements, distribution, and functions in smooth muscle / Pharmacol Rev 49(2):157~230
Thorneloe KS / 2005 / Ion channels in smooth muscle: regulators of intracellular calcium and contractility / Can J Physiol Pharmacol 83(3):215~242
Sanders KM / 2006 / Interstitial cells of cajal as pacemakers in the gastrointestinal tract / Annu Rev Physiol 68:307~343
Bolton TB / 2006 / Calcium events in smooth muscles and their interstitial cells; physiological roles of sparks / J Physiol 570(1):5~11
Karaki H / 1997 / Calcium movements, distribution, and functions in smooth muscle / Pharmacol Rev 49(2):157~230
Thorneloe KS / 2005 / Ion channels in smooth muscle: regulators of intracellular calcium and contractility / Can J Physiol Pharmacol 83(3):215~242
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UCI(KEPA) : I410-ECN-0101-2013-510-001228146