인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 저자정보
피인용 0
초록·키워드
Effects of methanol extracts from Artemisa iwayomogi (AI), Ganoderma lucidum (GL), Hericium erinaceus (HE), G. lucidum cultivated with A. iwayomogi (GLA), and H. erinaceus cultivated with A. iwayomogi (HEA) on biotransformation of aflatoxin B1 into aflatoxin B1-8,9-epoxide (AFBO) were evaluated. HEA showed the most potent inhibitory effect on AFBO formation, whereas that of HE was lower, possibly due to the changes in chemical components of the culture broth after the addition of AI. HEA also had stronger anti-complementary activity than HE. These results indicate the cultivation of HE with AI enhanced cancer preventive activity and host defense system. Anti-complementary activity and inhibitory effect on the AFBO formation of GLA were lower than those of GL. Low anti-complementary activities should specify low inhibitory effects on AFBO formation. Anticarcinogenic studies using natural products have been focused on the inhibitory effects in suppressing the carcinogenic effects of aflatoxins (Fig. 1) (6). Due to its potential carcinogenicity to animals and birds, aflatoxin B1 (1, Fig. 1) poses the most threat to public health and international trade (7, 8). One of the carcinogenic mechanism of aflatoxins is the formation of a single initial DNA adduct by aflatoxin B1-8,9-epoxide (AFBO) (2, Fig. 1) with a guanyl N7 atom in the DNA sequence (9). The AFBO formation is primarily catalyzed by CYP450 3A4 in human (10). Therefore, cancer chemoprevention studies have been focused on finding phytochemicals to disrupt the epoxidation reaction of aflatoxin B1. In addition, many studies have shown that various polymers from mushrooms possess some immuno-modulation properties on the human complement system, such as anti-complementary and interferon-inducing activities, that play pivotal roles in the defense system (11-13). The anti-complementary activities of various mushrooms have been extensively investigated for their fruiting bodies, mycelium, and culture broth and was revealed to be related to anti-tumor actions of mushrooms (14). In our study, we investigated the effects of five methanol extracts of oriental medicinal sources on the formation of the 8,9-epoxide derivative from aflatoxin B1. We also show that anti-complementary effects of the five methanol extracts are proportionate to the inhibitory effects on the AFBO formation.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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UCI(KEPA) : I410-ECN-0101-2013-573-001531363
