A general procedure for the optimal design of a micro-channel heat exchanger for heat pump systems is presented. For this design, a performance analysis program that can reflect the various geometric variables of the micro-channel heat exchanger was developed. The deviation between simulated and experiment results of previous research was within 4% for the heat transfer rate. To prove the feasibility of the optimal design process, the performance of the reference heat exchanger was compared to that of the optimized heat exchanger. The JFair and PECV of the optimized heat exchanger were enhanced by 14% and 26%, respectively.