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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.2
- 수록면
- 761 - 774 (14page)
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This study was to investigated that the effect of a-lipoic acid (ALA) supplementation on protection of the organs damages dependent on exercise-induced stress of rats fed a high fat diet. Thirty-two SD rats, 6 week old, were randomly divided into four groups (HS: high fat diet sedentary group, n=8; HE: high fat diet exercise group, n=8: AS: α-lipoic acid supplemented diet sedentary group, n=8; AE: α-lipoic acid supplemented diet exercise group, n=8, In the exercise group, the rats were performing a single bout of swimming exercise for 120 min (temp: 35±1℃, depth: 50㎝, radius: 25㎝, 3% load/weight). After exercise, the rats killed immediately by withdrawing blood from left ventricle under light diethyl ether anesthesia. In the result of body compositions, changes occurred in final body weight (HS vs AS, HE vs AE: p＜.01), FER (HS vs AS, HE vs AE: p＜.01), PIT (HS vs AS, HE vs AE: p＜.01), and EFT (HS vs AS: p＜.05, HE vs AE: p＜.01) by ALA supplementation. In the blood components, serum TG level of HE and AE groups were significantly higher than that of the HS and AS groups (p＜.01), respectively. In addition, MDA content in the liver and muscle of AS group was significantly lower than that of the HS group (p＜.01). In the SOD activity, changes occurred in the kidney (HE vs HS, HS vs AS: p＜.01), red gastrocnemius muscle (AE vs HE: p＜.01), and white gastrocnemius muscle (AE vs AS, AE vs HE: p＜.05), respectively. In the GPx activity, changes occurred in the kidney (HE vs HS: p＜.05, AS vs HS, AE vs AS: p＜.01), heart (AS vs HS: p＜.05), liver (AS vs HS: p＜.05, AE vs AS, AE vs HE: p＜.01), and white gastrocnemius muscle (AE vs AS, AE vs HE: p＜.05), respectively. From these results, ALA supplementation has a protective effect of the organs damage dependent on single bout of exercise-induced stress because ALA supplementation increased GPx activity in the kidney, liver, and heart, in particular, GPx activity was significantly increased after single bout of swimming exercise in the muscle as well.
목차
Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과
Ⅳ. 논의
Ⅴ. 결론
참고문헌
참고문헌 (49)
참고문헌 신청
1. [학술지(정기간행물)] - 박소은 / 2010 / 운동부하가 흰쥐의 지방대사율 및 렙틴에 미치는 영향 / 한국체육학회지 49 (4) : 447 ~ 454
2. [학술지(정기간행물)] - 박재용 / 2009 / ALA 섭취와 수영운동이 고지방식이 흰쥐의 근섬유 형태에 따른 지질과산화와 SOD 단백질 발현에 미치는 영향 / Journal of Exercise Nutrition & Biochemistry 13 (4) : 257 ~ 264
4. [학술지(정기간행물)] - Beddhu, S. / 2004 / The body mass index paradox and an obesity, inflammation, and atherosclerosis syndrome in chronic kidney disease / Semin Dial 17 : 229 ~ 232
5. [학술지(정기간행물)] - Buege, J. A. / 1978 / Microsomal lipid peroxidation / Methods Enzymol 52 : 302 ~ 310
6. [학술지(정기간행물)] - Cameron, N. E. / 1998 / Effect of alpha-lipoic acid on neurovascular function in diabetic rats : interaction with essential fatty acid / Diabetologia 41 : 390 ~ 399
2. [학술지(정기간행물)] - 박재용 / 2009 / ALA 섭취와 수영운동이 고지방식이 흰쥐의 근섬유 형태에 따른 지질과산화와 SOD 단백질 발현에 미치는 영향 / Journal of Exercise Nutrition & Biochemistry 13 (4) : 257 ~ 264
4. [학술지(정기간행물)] - Beddhu, S. / 2004 / The body mass index paradox and an obesity, inflammation, and atherosclerosis syndrome in chronic kidney disease / Semin Dial 17 : 229 ~ 232
5. [학술지(정기간행물)] - Buege, J. A. / 1978 / Microsomal lipid peroxidation / Methods Enzymol 52 : 302 ~ 310
6. [학술지(정기간행물)] - Cameron, N. E. / 1998 / Effect of alpha-lipoic acid on neurovascular function in diabetic rats : interaction with essential fatty acid / Diabetologia 41 : 390 ~ 399
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UCI(KEPA) : I410-ECN-0101-2013-692-001764211