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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.3
- 수록면
- 11 - 16 (6page)
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이 논문의 연구 히스토리 (2)
2012
Spermatotoxic effects of α-chlorohydrin in rats
Sung-Hwan Kim
,
In-Chul Lee
,
Jeong-Hyeon Lim
외 6명
Laboratory Animal Research
2012.03
학술저널
Ameliorative effects of pine bark extract on spermatotoxicity of α-chlorohydrin in rats
Sung-Hwan Kim
,
In-Chul Lee
,
Changjong Moon
외 2명
한국실험동물학회 학술발표대회 논문집
2012.02
학술대회자료
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초록· 키워드
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This study was conducted to investigate the potential effects of α-chlorohydrin (ACH) on epididymal function and antioxidant system in male rats. The test chemical was administered to male rats by gavage at doses of 0, 3, 10, and 30 mg/kg/day for 7 days. Twenty-four male rats were randomly assigned to four experimental groups, with six rats in each group. Spermatotoxicity was assessed by measurement of reproductive organ weight, testicular sperm head count, epididymal sperm motility and morphology, histopathologic examination, and oxidative damage analysis in rats. At 30 mg/kg/day, an increase in the incidence of clinical signs, epididymis weight, and gross necropsy findings of the epididymis, a decrease in the sperm motility, and an increased incidence of histopathological changes of the epididymis were observed in a dose-dependent manner. At 10 mg/kg/day, an increased incidence of clinical signs and histopathological changes and decreased sperm motility were observed. In the oxidative damage analysis, an increase in the malondialdehyde concentration and a decrease in the glutathione content and glutathione peroxidase and catalase activities in the epididymal tissue were detected at ≥3 mg/kg/day. The results show that graded doses of ACH elicit depletion of the antioxidant defense system and that the spermatotoxicity of ACH may be due to the induction of oxidative stress.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Harrison PT / 1997 / Reproductive health in humans and wildlife: are adverse trends associated with environmental chemical exposure / Sci Total Environ 205 (2) : 97 ~ 106
2. [학술지(정기간행물)] - Kavlock RJ / 1996 / Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop / Environ Health Perspect 104 : 715 ~ 740
3. [단행본] - U.S. Environmental Protection Agency / 2006 / Alpha-chlorohydrin: Human health risk assessment for proposed use as a rodenticide / USEPA
4. [학술지(정기간행물)] - Cooper ER / 1974 / Effects of alpha-chlorohydrin and related compounds on the reproductive organs and fertility of the male rat / J Reprod Fertil 38 (2) : 379 ~ 386
5. [학술지(정기간행물)] - Jelks K / 2001 / α-chlorohydrin induced changes in sperm fertilizing ability in the rat: association with diminished sperm ATP levels and motility / Reprod Toxicol 15 (1) : 11 ~ 20
2. [학술지(정기간행물)] - Kavlock RJ / 1996 / Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop / Environ Health Perspect 104 : 715 ~ 740
3. [단행본] - U.S. Environmental Protection Agency / 2006 / Alpha-chlorohydrin: Human health risk assessment for proposed use as a rodenticide / USEPA
4. [학술지(정기간행물)] - Cooper ER / 1974 / Effects of alpha-chlorohydrin and related compounds on the reproductive organs and fertility of the male rat / J Reprod Fertil 38 (2) : 379 ~ 386
5. [학술지(정기간행물)] - Jelks K / 2001 / α-chlorohydrin induced changes in sperm fertilizing ability in the rat: association with diminished sperm ATP levels and motility / Reprod Toxicol 15 (1) : 11 ~ 20
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UCI(KEPA) : I410-ECN-0101-2013-510-001698880