지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2012.5
- 수록면
- 166 - 170 (5page)
이용수
초록· 키워드
오류제보하기
There is much evidence suggesting that the development of cardiovascular diseases such as atherosclerosis and aneurysm are influenced by local hemodynamic environment. In particular, the wall shear stress, which is known to be one of the most important hemodynamic factors, has been demonstrated to be strongly correlated with biological responses. In the majority of vascular structure, vessel of interest appears relatively straight, the wall shear stress were estimated based on an assumption of fully developed axisymmetric velocity profile. However, small amplitude secondary curvature (minor wiggle) vessels rather than straight tubes can normally be observed in in vivo vascular system. This small amplitude sinusoidal wavy or helical geometry may have some clinical implication on the thrombosis and atherosclerosis by the mechanism of secondary flow mixing.
In this study, we conducted numerical simulations on laminar flow in sinusoidal wavy tubes for Reynolds number in the range of physiological condition and investigated flow structures and particle trajectories. For extensive comparisons, we employed pulsatile inflow conditions derived from in vivo measurements.
The results showed that small amplitude secondary curvature has significant influence on the nature of flow patterns and particle mixing mechanism. This implies that characterizing accurate geometry is essential in accurate predicting of in vivo hemodynamics and may motivate further study on any possibility of reflection of secondary flow on vascular remodeling and pathobiology.
In this study, we conducted numerical simulations on laminar flow in sinusoidal wavy tubes for Reynolds number in the range of physiological condition and investigated flow structures and particle trajectories. For extensive comparisons, we employed pulsatile inflow conditions derived from in vivo measurements.
The results showed that small amplitude secondary curvature has significant influence on the nature of flow patterns and particle mixing mechanism. This implies that characterizing accurate geometry is essential in accurate predicting of in vivo hemodynamics and may motivate further study on any possibility of reflection of secondary flow on vascular remodeling and pathobiology.
목차
1. Introduction
2. Method
3. Results and discussion
4. Conclusion
Acknowledgement
Reference
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UCI(KEPA) : I410-ECN-0101-2013-422-002847946