지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.6
- 수록면
- 390 - 397 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: Ischemia and reperfusion (I/R) injury is a major cause of hepatic failure after liver surgery, but there is no direct method to monitor it in real-time (like an electrocardiogram in heart disease) during surgery. Recently we found the possible role of bioelectrical impedance (BEI) to monitor I/R injury in liver. But the mechanism responsible for ischemia-related BEI changes has not been clearly determined.
Methods: The authors used an LCR meter to quantify BEI changes at 0.12 ㎑. Livers were subjected to 70% partial ischemia for 120 minutes, and ATP contents, cation changes in extracellular fluid (ECF; determined using an in vivo intracellular microdialysis technique), hepatocyte sizes, and histological changes were then examined.
Results: Liver tissue BEI was found to increase gradually during the first 60 minutes of ischemia and then tended to plateau. During the same period, intracellular ATP contents decreased to below 20% of the baseline level, [Na?] in ECF decreased from 150.4±3.8 to 97.8±10.6 mmol/L, and [K?] in ECF increased from 7.5±0.3 to 34.3±5.5 mmol/L during the first 60 minutes of ischemia. Hepatocyte diameter increased by ∼20% during the first 60 minutes of ischemia.
Conclusion: This study suggests that BEI changes during hepatic ischemia are probably caused by sodium and potassium concentration changes in the ECF due to reduced intracellular ATP contents.
Methods: The authors used an LCR meter to quantify BEI changes at 0.12 ㎑. Livers were subjected to 70% partial ischemia for 120 minutes, and ATP contents, cation changes in extracellular fluid (ECF; determined using an in vivo intracellular microdialysis technique), hepatocyte sizes, and histological changes were then examined.
Results: Liver tissue BEI was found to increase gradually during the first 60 minutes of ischemia and then tended to plateau. During the same period, intracellular ATP contents decreased to below 20% of the baseline level, [Na?] in ECF decreased from 150.4±3.8 to 97.8±10.6 mmol/L, and [K?] in ECF increased from 7.5±0.3 to 34.3±5.5 mmol/L during the first 60 minutes of ischemia. Hepatocyte diameter increased by ∼20% during the first 60 minutes of ischemia.
Conclusion: This study suggests that BEI changes during hepatic ischemia are probably caused by sodium and potassium concentration changes in the ECF due to reduced intracellular ATP contents.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (17)
참고문헌 신청
1. [학술지(정기간행물)] - Kun S / 2003 / Algorithm for tissue ischemia estimation based on electrical impedance spectroscopy / IEEE Trans Biomed Eng 50 : 1352 ~ 1359
2. [학술지(정기간행물)] - Konishi Y / 1995 / Electrical properties of extracted rat liver tissue / Res Exp Med (Berl) 195 : 183 ~ 192
4. [학술지(정기간행물)] - Mei Lan Cui / 2010 / Bioelectrical Impedance May Predict Cell Viability During Ischemia and Reperfusion in Rat Liver / Journal of Korean Medical Science 25 (4) : 577 ~ 582
6. [학술지(정기간행물)] - Rees AE / 1999 / Sensitivity of multiple frequency bioelectrical impedance analysis to changes in ion status / Physiol Meas 20 : 349 ~ 362
7. [학술지(정기간행물)] - Camargo CA Jr / 1997 / Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent / Hepatology 26 : 1513 ~ 1520
2. [학술지(정기간행물)] - Konishi Y / 1995 / Electrical properties of extracted rat liver tissue / Res Exp Med (Berl) 195 : 183 ~ 192
4. [학술지(정기간행물)] - Mei Lan Cui / 2010 / Bioelectrical Impedance May Predict Cell Viability During Ischemia and Reperfusion in Rat Liver / Journal of Korean Medical Science 25 (4) : 577 ~ 582
6. [학술지(정기간행물)] - Rees AE / 1999 / Sensitivity of multiple frequency bioelectrical impedance analysis to changes in ion status / Physiol Meas 20 : 349 ~ 362
7. [학술지(정기간행물)] - Camargo CA Jr / 1997 / Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent / Hepatology 26 : 1513 ~ 1520
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
허혈-재관류 손상 후 흰쥐 간세포 생존능의 평가
Annals of Surgical Treatment and Research
2007 .07
-
백서 신경에서 관찰한 허혈-재관류 손상 후 양상과 회복
Annals of Rehabilitation Medicine
2003 .01
-
Bowel ischemia
대한외과학회 학술대회 초록집
2014 .11
-
The Effect that the Application of Time-Based Electrolysis Has on Acute Ischemia
Journal of international academy of physical therapy research
2015 .01
-
Mesenteric Ischemia
대한외과학회 학술대회 초록집
2019 .05
-
Ischemia reperfusion injury of liver and development of an experimental platform
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Effect of Renal Ischemia in Tetraethylammonium Transport in Rabbit Renal Coritcal Slices
대한생리학회지
1991 .01
-
Effect of Preconditioning Ischemia on Endothelial Dysfunction Produced by Ischemia-Reperfusion in Rabbit Coronary Artery
대한생리학회지
1995 .01
-
Role of UCP2 Expression after Hepatic Warm Ischemia-Reperfusion in the Rat
Gut and Liver
2011 .01
-
간의 허혈 재관류 손상 측정 도구로서의 Bioelectrical Impedance의 의의
Annals of Hepato-Biliary-Pancreatic Surgery
2006 .03
-
인공 호흡기 적용에 따른 심근 허혈의 발생에 관한 연구
Tuberculosis and Respiratory Diseases
1999 .01
-
Analysis of Spatial and Temporal Protein Expression in the Cerebral Cortex after Ischemia-Reperfusion Injury
Journal of Clinical Neurology
2014 .01
-
The Neuroprotective Effect of Kefir on Spinal Cord Ischemia/Reperfusion Injury in Rats
대한신경외과학회지
2015 .01
-
전뇌를 일과성 허혈시킨 모래쥐 해마부위의 형태학적 변화
대한뇌졸중학회지
2000 .01
-
The Role of Oxygen Free Radicals and Phospholipase $A_2$ in Ischemia-reperfusion Injury to the Liver
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1995 .01
-
Experimental Study of Jaeumgenby-Tang Gamypang on the Anti Ischemia Mechanism in Cerebral Ischemia Rats
대한동의병리학회 학술대회논문집
2003 .07
-
흰쥐의 신허혈에서 HPLC를 이용한 핵산대사산물의 분석
영남의대학술지
1992 .01
-
간의 허혈시간이 간기능에 미치는 영향
Annals of Surgical Treatment and Research
1979 .10
-
Protective Effect of Compound K After Global Ischemia in Rat Heart
고려인삼학회 학술대회
2009 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0