지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.11
- 수록면
- 302 - 306 (5page)
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초록· 키워드
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Purpose: No tumor-specific markers for gastric cancer are currently known, although various tumor markers have been utilized. CEA, CA19-9 and AFP are the most commonly used tumor markers for gastric cancer. The aim of this study is to evaluate the prognostic significance of the preoperative CEA, CA19-9 and AFP levels in patients with gastric cancer.
Methods: A total of 366 patients who underwent curative surgery for gastric cancer were analyzed. The clinicopathologic characteristics and disease-free survival rate of the patients were compared between the positive and negative CEA, CA19-9 and AFP groups of patients, respectively. Also, the prognostic significance of each tumor marker was assessed by multivariate analysis.
Results: The CEA, CA19-9 and AFP levels were elevated in 14.2%, 7.9% and 19.1% of the patients, respectively. Serosal invasion and advanced cancer were more frequently found in the groups of patients who were positive for CEA and CA19-9 (P＜0.05). More lymph node metastasis and an advanced tumor stage were found in the group of patients who were positive for CA19-9 (P＜0.05). On univariate analysis, the disease-free survival rate was significantly lower in the CA19-9 positive group (P＜0.05). Serosal invasion and lymph node metastasis were the only significant prognostic factors on multivariate analysis.
Conclusion: CEA, CA19-9 and AFP have proved unhelpful for the early detection of gastric cancer due to the low positive rate. CEA and AFP have no prognostic significance and only CA19-9 can be useful for estimating the severity of gastric cancer and as a limited prognostic factor for gastric cancer patients.
Methods: A total of 366 patients who underwent curative surgery for gastric cancer were analyzed. The clinicopathologic characteristics and disease-free survival rate of the patients were compared between the positive and negative CEA, CA19-9 and AFP groups of patients, respectively. Also, the prognostic significance of each tumor marker was assessed by multivariate analysis.
Results: The CEA, CA19-9 and AFP levels were elevated in 14.2%, 7.9% and 19.1% of the patients, respectively. Serosal invasion and advanced cancer were more frequently found in the groups of patients who were positive for CEA and CA19-9 (P＜0.05). More lymph node metastasis and an advanced tumor stage were found in the group of patients who were positive for CA19-9 (P＜0.05). On univariate analysis, the disease-free survival rate was significantly lower in the CA19-9 positive group (P＜0.05). Serosal invasion and lymph node metastasis were the only significant prognostic factors on multivariate analysis.
Conclusion: CEA, CA19-9 and AFP have proved unhelpful for the early detection of gastric cancer due to the low positive rate. CEA and AFP have no prognostic significance and only CA19-9 can be useful for estimating the severity of gastric cancer and as a limited prognostic factor for gastric cancer patients.
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고찰
결론
REFERENCES
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Gutman AB / 1938 / An “Acid” phosphatase occurring in the serum of patients with metastasizing carcinoma of the prostate gland / J Clin Invest 17 : 473 ~ 478
2. [학술지(정기간행물)] - Koga T / 1987 / The clinical usefulness of preoperative CEA determination in gastric cancer / Jpn J Surg 17 : 342 ~ 347
3. [학술지(정기간행물)] - Nakane Y / 1994 / Correlation of preoperative carcinoembryonic antigen levels and prognosis of gastric cancer patients / Cancer 73 : 703 ~ 708
4. [학술지(정기간행물)] - Wanebo HJ / 1978 / Preoperative carcinoembryonic antigen level as a prognostic indicator in colorectal cancer / N Engl J Med 299 : 448 ~ 451
5. [학술지(정기간행물)] - Gaspar MJ / 2001 / Prognostic value of carcinoembryonic antigen, CA 19-9 and CA 72-4 in gastric carcinoma / Tumour Biol 22 : 318 ~ 322
2. [학술지(정기간행물)] - Koga T / 1987 / The clinical usefulness of preoperative CEA determination in gastric cancer / Jpn J Surg 17 : 342 ~ 347
3. [학술지(정기간행물)] - Nakane Y / 1994 / Correlation of preoperative carcinoembryonic antigen levels and prognosis of gastric cancer patients / Cancer 73 : 703 ~ 708
4. [학술지(정기간행물)] - Wanebo HJ / 1978 / Preoperative carcinoembryonic antigen level as a prognostic indicator in colorectal cancer / N Engl J Med 299 : 448 ~ 451
5. [학술지(정기간행물)] - Gaspar MJ / 2001 / Prognostic value of carcinoembryonic antigen, CA 19-9 and CA 72-4 in gastric carcinoma / Tumour Biol 22 : 318 ~ 322
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위암 환자에서 수술 전 혈청 CEA, CA 19-9, AFP측정의 예후 인자로서의 의의
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위험선택과 종양표식자 - CEA와 AFP에 대해서 -
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십이지장 팽대부 주위암에서 혈중 CEA, CA19-9, CA125 수치변화의 임상적 유용성에 관한 연구
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Relationship between Preoperative Serum CA15-3 and CEA Levels and Clinicopathological Parameters in Breast Cancer
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위암환자의 위암 조직과 문맥혈액 및 말초 정맥혈액에서 CEA와 CA19-9의 발현 및 측정치
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1999 .10
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Predictive Value of Preoperative Serum CEA, CA19-9 and CA125 Levels for Peritoneal Metastasis in Patients with Gastric Carcinoma
Cancer Research and Treatment
2004 .01
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위암 환자의 문맥혈액 및 말초 정맥혈에서 측정한 종양 표지자의 비교
Annals of Surgical Treatment and Research
1999 .04
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Changing patterns of Serum CEA and CA199 for Evaluating the Response to First-line Chemotherapy in Patients with Advanced Gastric Adenocarcinoma
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Serum CA 19-9 and CEA Levels as a Prognostic Factor in Pancreatic Adenocarcinoma
Yonsei Medical Journal
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UCI(KEPA) : I410-ECN-0101-2013-514-002689307