지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.4
- 수록면
- 267 - 273 (7page)
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초록· 키워드
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Purpose: The indocyanine clearance rate has been identified as an independent prognostic factor in patients with hepatocellular carcinoma (HCC). However, in contrast to its well-documented value in measuring hepatic reserve function, the mechanism by which it exerts its prognostic effect is not precisely understood.
Methods: We analyzed the clinical and pathological data, including preoperative ICG-R 15 and survival, of 80 patients with resectable HCC. The correlation between ICG-R15 and the degree of inflammation and fibrosis in non-cancerous liver tissue were investigated. The prognostic significance of ICG- R15 was also investigated in 67 patients with unresectable HCC who received transarterial chemoembolization.
Results: In patients with resectable HCC, the low ICG group (ICG-R15＜15%) showed an increased overall survival rate (P＜0.001) and disease-free survival rate (P＜0.01) compared to the high ICG group (ICG-R15≥15%). ICG-R15 was also a significant prognostic factor in the multivariate analysis. ICG-R15 showed a significant correlation with the degree of necroinflammation (P＜0.001) and the degree of fibrosis (P＜0.001). In patients with unresectable HCC, the low ICG group (ICG-R15＜30%) showed a significantly increased progression-free survival rate (P=0.037).
Conclusion: The results of the present study demonstrate that the ICG clearance rate can predict the degree of inflammation and fibrosis of non-cancerous hepatic parenchyma, and this capacity may explain the prognostic value of the ICG clearance rate in HCC patients.
Methods: We analyzed the clinical and pathological data, including preoperative ICG-R 15 and survival, of 80 patients with resectable HCC. The correlation between ICG-R15 and the degree of inflammation and fibrosis in non-cancerous liver tissue were investigated. The prognostic significance of ICG- R15 was also investigated in 67 patients with unresectable HCC who received transarterial chemoembolization.
Results: In patients with resectable HCC, the low ICG group (ICG-R15＜15%) showed an increased overall survival rate (P＜0.001) and disease-free survival rate (P＜0.01) compared to the high ICG group (ICG-R15≥15%). ICG-R15 was also a significant prognostic factor in the multivariate analysis. ICG-R15 showed a significant correlation with the degree of necroinflammation (P＜0.001) and the degree of fibrosis (P＜0.001). In patients with unresectable HCC, the low ICG group (ICG-R15＜30%) showed a significantly increased progression-free survival rate (P=0.037).
Conclusion: The results of the present study demonstrate that the ICG clearance rate can predict the degree of inflammation and fibrosis of non-cancerous hepatic parenchyma, and this capacity may explain the prognostic value of the ICG clearance rate in HCC patients.
목차
서론
방법
결과
고찰
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Llovet JM / 2003 / Hepatocellular carcinoma / Lancet 362 : 1907 ~ 1917
2. [학술지(정기간행물)] - Thomas MB / 2005 / Hepatocellular carcinoma: the need for progress / J Clin Oncol 23 : 2892 ~ 2899
3. [학술지(정기간행물)] - Adachi E / 1995 / Risk factors for intrahepatic recurrence in human small hepatocellular carcinoma / Gastroenterology 108 : 768 ~ 775
4. [학술지(정기간행물)] - Cha C / 2003 / Predictors and patterns of recurrence after resection of hepatocellular carcinoma / J Am Coll Surg 197 : 753 ~ 758
5. [학술지(정기간행물)] - Hasegawa S / 1999 / Factors that predict intrahepatic recurrence of hepatocellular carcinoma in 81 patients initially treated by percutaneous ethanol injection / Cancer 86 : 1682 ~ 1690
2. [학술지(정기간행물)] - Thomas MB / 2005 / Hepatocellular carcinoma: the need for progress / J Clin Oncol 23 : 2892 ~ 2899
3. [학술지(정기간행물)] - Adachi E / 1995 / Risk factors for intrahepatic recurrence in human small hepatocellular carcinoma / Gastroenterology 108 : 768 ~ 775
4. [학술지(정기간행물)] - Cha C / 2003 / Predictors and patterns of recurrence after resection of hepatocellular carcinoma / J Am Coll Surg 197 : 753 ~ 758
5. [학술지(정기간행물)] - Hasegawa S / 1999 / Factors that predict intrahepatic recurrence of hepatocellular carcinoma in 81 patients initially treated by percutaneous ethanol injection / Cancer 86 : 1682 ~ 1690
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UCI(KEPA) : I410-ECN-0101-2013-514-002693323