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(Samsung Biomedical Research Institute) (Samsung Biomedical Research Institute) (Pohang University of Science and Technology) (Pohang University of Science and Technology) (Samsung Medical Center) (Samsung Medical Center) (Samsung Medical Center) (Samsung Medical Center)
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대한외과학회 대한외과학회 학술대회 초록집 2010년도 추계 학술대회(2)
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    (Purpose) Malignant fibrous histiocytoma (MFH), now termed high-grade undifferentiated pleomorphic sarcoma, is an aggressive soft tissue sarcoma with a poor prognosis. Despite healthcare improvement, conventional therapy has been limited due to the large resistance of MFH. (Methods) To overcome this problems, we studied a new way using adipose tissue derived mesenchymal stem cells (AD-MSC) modified to secrete tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a protein that induces apoptosis in cancer cells but not normal cells. (Results) First of all, we studied tumor specific cytotoxicity of TRAIL, the result showed that TRAIL caused cell death in a dose dependent manner of rhTRAIL protein, 60% of cell death was induced in MFH at low concentration of 10ng/ml, but not in MSC even at high concentration. ... 전체 초록 보기

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