지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.5
- 수록면
- 288 - 295 (8page)
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Purpose: Insulin-like growth factors (IGFs) regulate a wide range of biological functions including cell proliferation, differentiation, and apoptosis through paracrine and autocrine mechanisms. Accordingly, the present study analyzed polymorphisms of IGF genes and their impact on the prognosis for patients with gastrointestinal stromal tumors (GISTs). Methods: Two hundred-thirteen consecutive patients with GISTs who underwent curative surgery from 5 medical centers were enrolled in the present study. The genomic DNA was extracted from paraffin-embedded tumor tissue, and four IGF-1 (＋2995C/A, ＋533C/T, IVS2-16540A/G, Ex4-177G/C) and one IGF-2 (IVS1＋1280A/G) gene polymorphisms were determined using a Sequenom MassARRAY system. Results: With a median follow-up of 18.4 months, the estimated 5-year relapse-free survival and overall survival rates were 69.9% and 86.7%, respectively. In a multivariate analysis including age, gender, primary site of disease, pathology, and risk stratification, no significant association was observed between the polymorphism of the IGF-1 and IGF-2 genes and survival. Conclusion: None of the five IGF-1 and IGF-2 gene polymorphisms investigated in this study was found to be an independent prognostic marker for Korean patients with surgically resected GIST. However, further studies on a larger scale are warranted to clarify the role of IGF-1 and IGF-2 gene polymorphisms as a prognostic biomarker for GIST patients.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONFLICTS OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (25)
참고문헌 신청
1. [학술지(정기간행물)] - Furstenberger G / 2002 / Insulin-like growth factors and cancer / Lancet Oncol 3 : 298 ~ 302
2. [학술지(정기간행물)] - Werner H / 2000 / New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia / Cell Mol Life Sci 57 : 932 ~ 942
3. [학술지(정기간행물)] - Giovannucci E / 2001 / Insulin, insulin-like growth factors and colon cancer: a review of the evidence / J Nutr 131 (11 Suppl) : 3109S ~ 3120S
4. [학술지(정기간행물)] - Kim WY / 2009 / Elevated epithelial insulin-like growth factor expression is a risk factor for lung cancer development / Cancer Res 69 : 7439 ~ 7448
5. [학술지(정기간행물)] - Ryan PD / 2008 / The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer / Oncologist 13 : 16 ~ 24
2. [학술지(정기간행물)] - Werner H / 2000 / New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia / Cell Mol Life Sci 57 : 932 ~ 942
3. [학술지(정기간행물)] - Giovannucci E / 2001 / Insulin, insulin-like growth factors and colon cancer: a review of the evidence / J Nutr 131 (11 Suppl) : 3109S ~ 3120S
4. [학술지(정기간행물)] - Kim WY / 2009 / Elevated epithelial insulin-like growth factor expression is a risk factor for lung cancer development / Cancer Res 69 : 7439 ~ 7448
5. [학술지(정기간행물)] - Ryan PD / 2008 / The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer / Oncologist 13 : 16 ~ 24
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UCI(KEPA) : I410-ECN-0101-2013-514-002669356