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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 219 - 226 (8page)
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초록· 키워드
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The acyl-CoA dehydrogenase, C-2 to C-3 short chain (ACADS) gene is known to be related with fat metabolism, especially coverts the fat to the energy sources in cattle. In human, the mutations in this gene cause SCAD deficiency, which is one of the fatty acid metabolism disorders. The ACADS gene is located on bovine chromosome 17. The objective of this study was to identify SNPs in Hanwoo ACADS gene and identify the relationships with economic traits. In this study, two SNPs, T1570G SNP in exon 2 and G13917A SNP in exon 4, were observed. Moreover, in the coding region, 2 missense mutations, T (Cys) → G (Trp) mutation at 1570 bp and G (Arg) → A (Gln) mutation at 13917 bp, were observed. These mutations were subjected to the PCR-RFLP for typing 198 Hanwoo animals. The observed genotype frequency for T1570G was 0.135 (TT), 0.860 (TG) and 0.005 (GG), respectively. Also, 0.900 (GG) and 0.100 (GA) were observed for the G13917A mutation. The association of these SNPs with four economic traits, CW (Carcass Weight), BF (Backfat Thickness), LMA (Longissimus Muscle Area), MS (Marbling Score), were also observed. The results indicated that no significant results were observed in all four traits (P＞0.05). This might indicate that further studies are ultimately needed to use the SNPs in ACADS gene in lager populations for effectively used for the marker assisted selection.
목차
Abstract
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과 및 고찰
Ⅳ. 결론
감사의 글
참고문헌
참고문헌 (35)
참고문헌 신청
1. [기타자료] - Barendse W. / 1999 / Assessing lipid metabolism. International patent application PCT/AU98/00882 / Patent Publication WO 99/23248
2. [학술지(정기간행물)] - Buchanan FC / 2002 / Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels / Genet. Sel. Evol 34 : 105 ~ 116
3. [학술지(정기간행물)] - Casas E / 2003 / Detection of quantitative trait loci for growth and carcass composition in cattle / J. Anim. Sci 81 (12) : 2976 ~ 2983
4. [학술지(정기간행물)] - Casas E / 2001 / A comprehensive search for quantitative trait loci affecting growth and carcass composition of cattle segregating alternative forms of the myostatin gene / J. Anim. Sci 79 (4) : 854 ~ 860
5. [학술지(정기간행물)] - Casas E / 2006 / Effects of calpastatin and micro-calpain markers in beef cattle on tenderness traits / J. Anim. Sci 84 (3) : 520 ~ 525
2. [학술지(정기간행물)] - Buchanan FC / 2002 / Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels / Genet. Sel. Evol 34 : 105 ~ 116
3. [학술지(정기간행물)] - Casas E / 2003 / Detection of quantitative trait loci for growth and carcass composition in cattle / J. Anim. Sci 81 (12) : 2976 ~ 2983
4. [학술지(정기간행물)] - Casas E / 2001 / A comprehensive search for quantitative trait loci affecting growth and carcass composition of cattle segregating alternative forms of the myostatin gene / J. Anim. Sci 79 (4) : 854 ~ 860
5. [학술지(정기간행물)] - Casas E / 2006 / Effects of calpastatin and micro-calpain markers in beef cattle on tenderness traits / J. Anim. Sci 84 (3) : 520 ~ 525
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UCI(KEPA) : I410-ECN-0101-2013-480-002670316