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자료유형
학술저널
저자정보
저널정보
계명대학교 생활과학연구소 과학논집 과학논집 제33집
발행연도
2007.12
수록면
33 - 43 (11page)

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A recent study reported that a diet rich in fiber is beneficial for prevent chronic disease. It therefore seemed desirable to find out whether the beneficial effect of high fiber diet on bone. Increasing dietary fiber increases endogenous calcium excretion. The ability to adapt depends upon the adequacy of an individual’s calcium intake. To study the effect of high fiber diet, two times amount of fiber which used for rats, on bone mineral density and bone mineral content in rats were performed. Forty female Sprague-Dawley rats(body weight 210±5 g) were divided into two groups, which were each randomly divided into two groups that were fed control and fiber supplemented(200%) diets for 5 weeks. All rats were fed on experimental diet and deionized water ad llibitum. Bone mineral density(BDM) and bone mineral content (BMC) were measured using PIXImus(GE Lunar Co, Wisconsin) in spine and femur. Serum alkaline phosphatase activity(ALP) and urinary DPD crosslinks va;ie were measured as markers of bone formation and resorption. The results of theis study indicae that body weight gain and food intake were nor significantly different between two groups. Serum Ca and P concentrations were not significantly different between two groups. Also serum ALP and crosslink value were not significantly different between two group. Spine BMD and femur BMD were not significantly different between two groups. However, urinary Ca was significantly increased in fiber supplemented group. In conclusion, the negative effect of high fiber diet on bone mineral density in rats was not shown on 5 weeks after feeding with two times amount of fiber supplementation which used for rats. But urinary calcium excretion was higher in supplemented than in control group. Excess fiber will not harm the skeleton if the calcium intake is adequate. However, further investigations of relations between ruinary calcium excretion and bone mineral density are warranted.


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〈Abstract〉
Ⅰ. 서론
Ⅱ. 연구방법 및 내용
Ⅲ. 결과 및 고찰
Ⅳ. 요약 및 결론
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