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논문 기본 정보

자료유형
학술저널
저자정보
Jia-Qi Chu (Animal, Plant and Fisheries Quarantine and Inspection Agency (QIA)) Su-Mi Kim (Animal, Plant and Fisheries Quarantine and Inspection Agency (QIA)) Kwang-Nyeong Lee (Animal, Plant and Fisheries Quarantine and Inspection Agency (QIA)) Jae-Ku Oem (Animal, Plant and Fisheries Quarantine and Inspection Agency (QIA)) Young-Joon Ko (Animal, Plant and Fisheries Quarantine and Inspection Agency (QIA)) Hyang-Sim Lee (Animal, Plant and Fisheries Quarantine and Inspection Agency (QIA)) Yong-Joo Kim (Animal, Plant and Fisheries Quarantine and Inspection Agency (QIA)) Jee-Yong Park (Animal, Plant and Fisheries Quarantine and Inspection Agency (QIA)) Kwang-Jae Kim (Animal, Plant and Fisheries Quarantine and Inspection Agency (QIA)) Satya Parida (Institute for Animal Health) Yooni Oh (Animal, Plant and Fisheries Quarantine and Inspection Agency (QIA)) David J. Paton (Institute for Animal Health) Yi-Seok Joo (Animal, Plant and Fisheries Quarantine and Inspection Agency (QIA)) Byounghan Kim (Animal, Plant and Fisheries Quarantine and Inspection Agency (QIA)) Jong-Hyeon Park (Institute for Animal Health)
저널정보
대한미생물학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY JOURNAL OF BACTERIOLOGY AND VIROLOGY Vol.42 No.3
발행연도
2012.9
수록면
224 - 231 (8page)

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Interferon is an important cytokine that plays a critical role in the initial host defense against viral infection. Recombinant human adenoviruses expressing human interferon-α (Ad-HIFNα) or pig interferon-β fused with interleukin-18 (Ad-PIFNβ-IL18) were constructed and used to induce an early protective response against foot and mouth disease (FMD). To analyze the antiviral effect, bovine thyroid and porcine kidney IBRS-2 cells and ICR mice were treated with Ad-HIFNα, Ad-PIFNβ-IL18, and cocktail of Ad-HIFNα and Ad-PIFNβ-IL18. The survival rate of suckling mice was monitored after foot and mouth disease virus (FMDV) challenge following intra-peritoneal (IP) administration of appropriate adenovirus. Indirect antigen ELISA was performed to evaluate inhibition of FMDV replication following challenge with the FMDV O, A, or Asia 1 serotypes in vitro. These recombinant adenoviruses reduced the replication of FMDV in susceptible cells, thereby decreasing the fatality in mice, suggesting that they can be a useful control method for the early protection against FMD infection in livestock after field trial.

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INTRODUCTION
MATERIAL AND METHODS
RESULTS
DISCUSSION
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2014-475-001381011