지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 34 - 39 (6page)
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초록· 키워드
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Chemotherapy induced alopecia (CIA) is one of the most common and emotionally traumatic side effects in cancer patient care. CIA occurs with an estimated incidence of 65% and negatively affects a patient°Øs perception of appearance, body image, attractiveness, and self-esteem. Patient who fear CIA may select regimens with less favorable outcomes or may refuse treatment.
CIA is caused by certain chemotherapeutics such as anthracyclines and taxanes. The incidence and severity of CIA depends on dose, administration route, rate, schedule, and peak blood level of the drug. The keratinocytes of hair follicle are susceptible to apoptosis induced by chemotherapeutics. Fortunately, CIA is usually reversible but permanent CIA also has been reported.
The major approaches to prevent or minimize CIA are by physical and pharmacological means. Several experimental studies to the development of pharmacological agents to overcome CIA are under evaluation. However, effective methods for preventing CIA are currently unavailable.
The management of CIA must be individualized based on the needs of each patient. An effective CIA treatment would likely require agents that are effective for chemotherapeutics with different action mechanisms and selective to hair follicles.
CIA is caused by certain chemotherapeutics such as anthracyclines and taxanes. The incidence and severity of CIA depends on dose, administration route, rate, schedule, and peak blood level of the drug. The keratinocytes of hair follicle are susceptible to apoptosis induced by chemotherapeutics. Fortunately, CIA is usually reversible but permanent CIA also has been reported.
The major approaches to prevent or minimize CIA are by physical and pharmacological means. Several experimental studies to the development of pharmacological agents to overcome CIA are under evaluation. However, effective methods for preventing CIA are currently unavailable.
The management of CIA must be individualized based on the needs of each patient. An effective CIA treatment would likely require agents that are effective for chemotherapeutics with different action mechanisms and selective to hair follicles.
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Abstract
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UCI(KEPA) : I410-ECN-0101-2014-513-001297046