지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 238 - 244 (7page)
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Purpose: Recent studies have reported improved perioperative and long-term outcomes for the initial postoperative results for patients with a huge HCC. The purpose of this study was to investigate the surgical outcomes of patients with a huge HCC and we wanted to identify any subgroup that would likely benefit from hepatic resection.
Methods: From January 1996 to August 2006, 55 patients were diagnosed with a huge HCC (≥ 10cm in diameter). All the tumors were classified as either the expanding nodular type or the non- expanding nodular type.
Results: The mean age of the patients was 50.6 years and 39 patients were male. The most common cause of liver disease was hepatitis B virus. The mean size of tumor was 11.9 cm. Microscopic liver cirrhosis was present in 17 patients. Twenty-three patients had tumors of the expanding nodular type. Curative resection was performed in 50 patients. The 5-year diseasefree and overall survival rates after resection were 35.8% and 41.0%, respectively. Univariate analysis revealed that surgical margins of ≤ 1.0, a non-curative resection, the non-expanding nodular type and microscopic vascular invasion were adverse prognostic factors for survival. Multivariate analysis indicated that the gross tumor classification (expanding nodular vs. nonexpanding nodular) was the only independent prognostic factor.
Conclusions: Huge HCC is not a homogenous group and the gross tumor pattern may represent the biologic behavior of huge HCC. Because the outcome of surgical treatment is far better than that of non-surgical treatment, resection should be actively considered for patients with a huge HCC. An expanding nodular type tumor is the best candidate for surgical resection.
Methods: From January 1996 to August 2006, 55 patients were diagnosed with a huge HCC (≥ 10cm in diameter). All the tumors were classified as either the expanding nodular type or the non- expanding nodular type.
Results: The mean age of the patients was 50.6 years and 39 patients were male. The most common cause of liver disease was hepatitis B virus. The mean size of tumor was 11.9 cm. Microscopic liver cirrhosis was present in 17 patients. Twenty-three patients had tumors of the expanding nodular type. Curative resection was performed in 50 patients. The 5-year diseasefree and overall survival rates after resection were 35.8% and 41.0%, respectively. Univariate analysis revealed that surgical margins of ≤ 1.0, a non-curative resection, the non-expanding nodular type and microscopic vascular invasion were adverse prognostic factors for survival. Multivariate analysis indicated that the gross tumor classification (expanding nodular vs. nonexpanding nodular) was the only independent prognostic factor.
Conclusions: Huge HCC is not a homogenous group and the gross tumor pattern may represent the biologic behavior of huge HCC. Because the outcome of surgical treatment is far better than that of non-surgical treatment, resection should be actively considered for patients with a huge HCC. An expanding nodular type tumor is the best candidate for surgical resection.
목차
서론
방법
결과
고찰
참고문헌
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Pawlik TM / 2005 / Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma / Arch Surg 140 : 450 ~ 457
2. [학술지(정기간행물)] - Capussotti L / 2007 / Liver resection for HCC with cirrhosis: Surgical perspectives out of EASL/AASLD guidelines / Eur J Surg Oncol
3. [학술지(정기간행물)] - Furuta T / 1992 / Hepatic resection for a hepatocellular carcinoma larger than 10 cm / J Surg Oncol 51 : 114 ~ 117
4. [학술지(정기간행물)] - Noguchi T / 1997 / Clinicopathologic factors influencing the long-term prognosis following hepatic resection for large hepatocellular carcinoma more than 10 cm in diameter / Semin Oncol 24 : 6 ~ 13
5. [학술지(정기간행물)] - Abdel-Wahab M / 2001 / Is resection for large hepatocellular carcinoma in cirrhotic patients beneficial? Study of 38 cases / Hepatogastroenterology 48 : 757 ~ 761
2. [학술지(정기간행물)] - Capussotti L / 2007 / Liver resection for HCC with cirrhosis: Surgical perspectives out of EASL/AASLD guidelines / Eur J Surg Oncol
3. [학술지(정기간행물)] - Furuta T / 1992 / Hepatic resection for a hepatocellular carcinoma larger than 10 cm / J Surg Oncol 51 : 114 ~ 117
4. [학술지(정기간행물)] - Noguchi T / 1997 / Clinicopathologic factors influencing the long-term prognosis following hepatic resection for large hepatocellular carcinoma more than 10 cm in diameter / Semin Oncol 24 : 6 ~ 13
5. [학술지(정기간행물)] - Abdel-Wahab M / 2001 / Is resection for large hepatocellular carcinoma in cirrhotic patients beneficial? Study of 38 cases / Hepatogastroenterology 48 : 757 ~ 761
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UCI(KEPA) : I410-ECN-0101-2014-514-001253910