지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 269 - 277 (9page)
이용수
초록· 키워드
오류제보하기
The purpose of this study was to understand the mechanism of cardiovascular disease (CVD) caused by exposure to hazardous chemicals. We investigated changes in the symptoms of metabolic syndrome, which is strongly related to CVD, and in levels of other CVD risk factors, with a special emphasis on the roles of catecholamines and oxidative stress. The results revealed that neither body mass index (BMI) nor waist and hip circumferences were associated with exposure to hazardous chemicals. Among metabolic syndrome criteria, only HDL-cholesterol level increased on exposure to hazardous chemicals. Levels of epinephrine (EP) and norepinephrine (NEP) were not influenced by exposure to hazardous chemicals; however, the total antioxidative capacity (TAC) reduced because of increased oxidative stress. Both hazardous chemical exposure level and metabolite excretion were related to EP, NEP, and the oxidative stress index (OSI). Logistic regression analysis with these factors as independent variables and metabolic syndrome criteria as dependent variables revealed that EP was associated with blood pressure, and NEP with metabolic syndrome in the chemicalexposed group. In conclusion, the results suggest that reactive oxygen species generated and oxidative stress due to exposure to hazardous chemicals act as mediators and cause changes in the physiological levels of EP and NEP to increase blood pressure. This ultimately leads to the development of CVD through increase in cholesterol, triglyceride, and blood glucose levels by lipid peroxidation.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (45)
참고문헌 신청
Al-Safi, S. A. / 2006 / Influence of family history and lifestyle on blood pressure and heart rate in young adults in Jordan / Public Health 120:1027~1032
Albright, J.A. / 1996 / Environmental pollutants and the immune system / Otolaryngol. Head Neck Surg 114:232~238
Allen, R. W. / 2012 / Modeling the residential infiltration of outdoor PM(2.5) in the multi-ethnic study of atherosclerosis and air pollution (MESA Air) / Environ. Health Perspect. 120:824~30
Baena, D.J.M. / 2005 / Cardiovascular diz az pidemiology and rizk factors in primary care / Revn. SP. Cardiol 58:367~373
Brunekreef, B. / 2009 / Effects of long-term exposure to traffic- related air pollution on respiratory and cardiovascular mortality in the Netherlands: the NLCS-AIR study / Res. Rep. Health Eff. Inst 139:5~71
Albright, J.A. / 1996 / Environmental pollutants and the immune system / Otolaryngol. Head Neck Surg 114:232~238
Allen, R. W. / 2012 / Modeling the residential infiltration of outdoor PM(2.5) in the multi-ethnic study of atherosclerosis and air pollution (MESA Air) / Environ. Health Perspect. 120:824~30
Baena, D.J.M. / 2005 / Cardiovascular diz az pidemiology and rizk factors in primary care / Revn. SP. Cardiol 58:367~373
Brunekreef, B. / 2009 / Effects of long-term exposure to traffic- related air pollution on respiratory and cardiovascular mortality in the Netherlands: the NLCS-AIR study / Res. Rep. Health Eff. Inst 139:5~71
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UCI(KEPA) : I410-ECN-0101-2014-513-000614650