지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives : This study was performed to evaluate the influence of different extracting solvents (water, methanol, ethanol, or n-hexane) on the anti-inflammatory efficacy of Scutellaria baicalensis (Lamiaceae), which has been used widely as a traditional herbal medicine for its anti-inflammatory properties.
Methods : The ability of each extract to inhibit the production of pro-inflammatory mediators such as NO, TNF-α, and PGE2 by lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells was measured.
Results : The results showed that extraction solvents (except n-hexane) for S. baicalensis showed significant inhibitory effects on NO, TNF-α and PGE<SUB>2</SUB> production. Especially, methanol was the solvent with the greatest activity against NO and PGE<SUB>2</SUB> production. However, there was no difference between the extracts for inhibitory activity of TNF-α.
Conclusion : The present study suggests that methanol is a superior extraction solvent than water, ethanol, or n-hexane for maintaining the anti-inflammatory effects of S. baicalensis.
Methods : The ability of each extract to inhibit the production of pro-inflammatory mediators such as NO, TNF-α, and PGE2 by lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells was measured.
Results : The results showed that extraction solvents (except n-hexane) for S. baicalensis showed significant inhibitory effects on NO, TNF-α and PGE<SUB>2</SUB> production. Especially, methanol was the solvent with the greatest activity against NO and PGE<SUB>2</SUB> production. However, there was no difference between the extracts for inhibitory activity of TNF-α.
Conclusion : The present study suggests that methanol is a superior extraction solvent than water, ethanol, or n-hexane for maintaining the anti-inflammatory effects of S. baicalensis.
목차
Introduction
Materials and Methods
Results and Discussion
Acknowledgements
References
참고문헌 (37)
참고문헌 신청
1. [학술지(정기간행물)] - Pulendran B / 2001 / Sensing pathogens and tuning immune responses / Science 293 (5528) : 253 ~ 256
2. [학술지(정기간행물)] - Kim HP / 2004 / Antiinflammatory plant flavonoids and cellular action mechanisms / J Pharmacol Sci 96 (3) : 229 ~ 245
3. [학술지(정기간행물)] - Lee JH / 2001 / Anti-inflammatory effect of the aqueous extract from Lonicera japonica flower is related to inhibition of NF-kappaB activation through reducing I-kappaBalpha degradation in rat liver / Int J Mol Med 7 (1) : 79 ~ 83
4. [학술지(정기간행물)] - Kubo M / 1984 / Studies on Scutellariae radix. VII. Anti-arthritic and antiinflammatory actions of methanolic extract and flavonoid components from Scutellariae radix / Chem Pharm Bull (Tokyo) 32 (7) : 2724 ~ 2729
5. [학술지(정기간행물)] - Zhang DY / 2003 / Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis / Cancer Res 63 (14) : 4037 ~ 4043
2. [학술지(정기간행물)] - Kim HP / 2004 / Antiinflammatory plant flavonoids and cellular action mechanisms / J Pharmacol Sci 96 (3) : 229 ~ 245
3. [학술지(정기간행물)] - Lee JH / 2001 / Anti-inflammatory effect of the aqueous extract from Lonicera japonica flower is related to inhibition of NF-kappaB activation through reducing I-kappaBalpha degradation in rat liver / Int J Mol Med 7 (1) : 79 ~ 83
4. [학술지(정기간행물)] - Kubo M / 1984 / Studies on Scutellariae radix. VII. Anti-arthritic and antiinflammatory actions of methanolic extract and flavonoid components from Scutellariae radix / Chem Pharm Bull (Tokyo) 32 (7) : 2724 ~ 2729
5. [학술지(정기간행물)] - Zhang DY / 2003 / Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis / Cancer Res 63 (14) : 4037 ~ 4043
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UCI(KEPA) : I410-ECN-0101-2014-519-000282176