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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: Inflammatory mediators, such as nitric oxide (NO), prostaglandin E2 (PGE₂) and pro-inflammatory cytokines, TNF-α and IL-1β play a critical role in inflammatory immune response. Therefore, intervention of inflammatory mediator production promises therapeutic benefit for treatment of many chronic inflammatory diseases, such as allergic asthma, rheumatoid arthritis, multiple sclerosis, septic shock and neurodegenerative diseases. In this study, the pharmacological effects of the flower MeOH extract Panax notoginseng (Notoginseng Flos; NF) on inflammation were investigated to address potential therapeutic or toxic effects.
Methods: RAW264.7 cells were treated with different concentrations of NF methanol (NF-M) extract in the presence or absence of LPS (1 ㎍/㎖ ).
Results: NF-M extract significantly inhibited LPS-induced production of NO, PGE₂ and pro-inflammatory cytokines, TNF-α and IL-1β in a dose-dependent manner. In addition, NF-M extract suppressed mRNA expressions and protein levels of iNOS, COX-2 and pro-inflammatory cytokines in LPS-stimulated RAW264.7 cells.
Conclusion: These results indicated that NF-M extract inhibits LPS-induced production of inflammatory mediators in macrophages and demonstrated that NF-M extract possesses anti-inflammatory properties in vitro.
Methods: RAW264.7 cells were treated with different concentrations of NF methanol (NF-M) extract in the presence or absence of LPS (1 ㎍/㎖ ).
Results: NF-M extract significantly inhibited LPS-induced production of NO, PGE₂ and pro-inflammatory cytokines, TNF-α and IL-1β in a dose-dependent manner. In addition, NF-M extract suppressed mRNA expressions and protein levels of iNOS, COX-2 and pro-inflammatory cytokines in LPS-stimulated RAW264.7 cells.
Conclusion: These results indicated that NF-M extract inhibits LPS-induced production of inflammatory mediators in macrophages and demonstrated that NF-M extract possesses anti-inflammatory properties in vitro.
목차
서론
실험
결과
고찰
결론
참고문헌
참고문헌 (37)
참고문헌 신청
1. [학술지(정기간행물)] - Bosca L / 2005 / Nitric oxide and cell viability in inflammatory cells: a role for NO in macrophage function and fate / Toxicology 208 (2) : 249 ~ 258
2. [학술지(정기간행물)] - Moncada S / 1999 / Nitric oxide: discovery and impact on clinical medicine / Journal of the Royal Society of Medicine 92 (4) : 164 ~ 169
3. [학술지(정기간행물)] - Nathan C / 1992 / Nitric oxide as a secretory product of mammalian cells / The FASEB journal 6 (2) : 3051 ~ 3064
4. [학술지(정기간행물)] - Turini ME / 2002 / Cyclooxygenase-2: a therapeutic target / Annual review of medicine 53 : 35 ~ 57
5. [학술지(정기간행물)] - Rocca B / 2002 / Cyclooxygenases and prostaglandins: shaping up the immune response / International immunopharmacology 2 (5) : 603 ~ 630
2. [학술지(정기간행물)] - Moncada S / 1999 / Nitric oxide: discovery and impact on clinical medicine / Journal of the Royal Society of Medicine 92 (4) : 164 ~ 169
3. [학술지(정기간행물)] - Nathan C / 1992 / Nitric oxide as a secretory product of mammalian cells / The FASEB journal 6 (2) : 3051 ~ 3064
4. [학술지(정기간행물)] - Turini ME / 2002 / Cyclooxygenase-2: a therapeutic target / Annual review of medicine 53 : 35 ~ 57
5. [학술지(정기간행물)] - Rocca B / 2002 / Cyclooxygenases and prostaglandins: shaping up the immune response / International immunopharmacology 2 (5) : 603 ~ 630
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UCI(KEPA) : I410-ECN-0101-2014-519-000284372