지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: This study was performed to investigate the effects of Semen Persicae (SP) on infarct volume, COX-2 protein expression in the middle cerebral artery occlusion (MCAo) rats.
Methods: Twenty-eight rats were randomly assigned to four groups (MCAo experimental group, MCAo control group, sham experimental group, control group). The middle cerebral artery (MCA) was occluded in the MCAo group by proximal focal cerebral ischemia rat model, while the MCA was not occluded in the sham group. SP extraction was administrated for 4 days to each experimental group. Neuroprotective effects were investigated by measurement of brain damage using 2, 3, 5-triphenyltetrazolium chloride staining and analysis of COX-2 protein expression by western blotting.
Results: The occurrence of infarct volume in the SP oral administration group decreased compared to the control group. COX-2 protein expression in the SP oral administration group decreased compared to the control group.
Conclusions: The present study demonstrates the effect of SP in reducing infarct volume and decreasing COX-2 expression.
Methods: Twenty-eight rats were randomly assigned to four groups (MCAo experimental group, MCAo control group, sham experimental group, control group). The middle cerebral artery (MCA) was occluded in the MCAo group by proximal focal cerebral ischemia rat model, while the MCA was not occluded in the sham group. SP extraction was administrated for 4 days to each experimental group. Neuroprotective effects were investigated by measurement of brain damage using 2, 3, 5-triphenyltetrazolium chloride staining and analysis of COX-2 protein expression by western blotting.
Results: The occurrence of infarct volume in the SP oral administration group decreased compared to the control group. COX-2 protein expression in the SP oral administration group decreased compared to the control group.
Conclusions: The present study demonstrates the effect of SP in reducing infarct volume and decreasing COX-2 expression.
목차
서론
실험
결과
고찰
결론
참고문헌
참고문헌 (43)
참고문헌 신청
1. [학술지(정기간행물)] - Lo EH / 2003 / Mechanisms, challenges and opportunities in stroke / Nat Rev Neurosci 4 (5) : 399 ~ 415
2. [인터넷자원] - / / http://www.kcvs.org/brain 119/brain02.html
3. [학술지(정기간행물)] - Janardhan V / 2004 / Mechanisms of ischemic brain injury / Curr Cardiol Rep 6 (2) : 117 ~ 123
4. [학술지(정기간행물)] - Govoni S / 2001 / The Cycloxygenase-2 inhibitor SC58236 is neuroprotective in an in vivo model of focal ischemia in the rat / Neurosci Lett 303 (2) : 91 ~ 94
5. [학술지(정기간행물)] - Salzberg-Brenhouse HC / 2003 / Inhibitors of cyclooxygenase-2, but not cyclooxygenase-1 provide structural and functional protection against quinolinic acid-induced neurodegeneration / J Pharmacol Exp Ther 30 (6) : 218 ~ 228
2. [인터넷자원] - / / http://www.kcvs.org/brain 119/brain02.html
3. [학술지(정기간행물)] - Janardhan V / 2004 / Mechanisms of ischemic brain injury / Curr Cardiol Rep 6 (2) : 117 ~ 123
4. [학술지(정기간행물)] - Govoni S / 2001 / The Cycloxygenase-2 inhibitor SC58236 is neuroprotective in an in vivo model of focal ischemia in the rat / Neurosci Lett 303 (2) : 91 ~ 94
5. [학술지(정기간행물)] - Salzberg-Brenhouse HC / 2003 / Inhibitors of cyclooxygenase-2, but not cyclooxygenase-1 provide structural and functional protection against quinolinic acid-induced neurodegeneration / J Pharmacol Exp Ther 30 (6) : 218 ~ 228
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UCI(KEPA) : I410-ECN-0101-2014-519-000284483