지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives : Yonnyuniksoogobon-dan (Yan Nian Yi Shou Gu Ben Dan 延年益壽固本丹) is composed of 11 herbs (Polygoni Mutiflori Radix, Lycii Radicis Cortex, Polia, Rehmanniae Radix, Rehmanniae Radix Preparat, Asparagi Radix, Liriopis Tuber, Lycii Fructus, Acori Graminei Rhizoma, Angelicae Acutiloba Radix, and Pini Folium) based on Yonryunggobon-dan (Yan Ling Gu Ben Dan 延齡固本丹) and Yonnyuniksoobulrho-dan (Yan Nian Yi Shou Bu Lao Dan 延年益壽不老丹). This study evaluated hair growth promoting effect of Yonnyuniksoogobon-dan on the shaved C57BL/6 mice.
Methods : Yonnyuniksoogobon-dan was treated by oral administration (Sample I) and oral administration plus skin application (Sample II) once a day for 12 days. Hair regrowth was photographically and histologically determined during the experimental period. Hair growth cycle related factors (EGF, TGF-β1) and vascular factors (VEGF, iNOS) were also determined with immunohistochemistry.
Results :
1. On gross observation of hair regrowth, Sample I and Sample II groups demonstrated acceleration of hair regrowth.
2. The hair regrowth index of the Sample I group increased significantly from 7 days (P<0.05) to 12 days (P<0.01) after the shave while that of the Sample II group significantly increased at 12 days (P<0.05).
3. On histological observation, both Sample I and Sample II groups demonstrated histological improvement and increases of number and diameter of the hair follicles.
4. EGF expressions on the root sheath of hair follicles were up-regulated in both Sample I and Sample II groups.
5. TGF-β1 expressions on the root sheath of hair follicles were not regulated in Sample I or Sample II groups.
6. VEGF expressions in the surrounding tissues of hair follicles were up-regulated in both Sample I and Sample II groups.
7. iNOS expressions in the surrounding tissues of hair follicles were down-regulated in both Sample I and Sample II groups.
Conclusions : These results suggest that Yonnyuniksoogobon-dan has hair growth-promoting activity and these effects relate to up-regulations of EGF and VEFG expressions and down-regulations of TGF-β1 and iNOS expressions on hair roots.
Methods : Yonnyuniksoogobon-dan was treated by oral administration (Sample I) and oral administration plus skin application (Sample II) once a day for 12 days. Hair regrowth was photographically and histologically determined during the experimental period. Hair growth cycle related factors (EGF, TGF-β1) and vascular factors (VEGF, iNOS) were also determined with immunohistochemistry.
Results :
1. On gross observation of hair regrowth, Sample I and Sample II groups demonstrated acceleration of hair regrowth.
2. The hair regrowth index of the Sample I group increased significantly from 7 days (P<0.05) to 12 days (P<0.01) after the shave while that of the Sample II group significantly increased at 12 days (P<0.05).
3. On histological observation, both Sample I and Sample II groups demonstrated histological improvement and increases of number and diameter of the hair follicles.
4. EGF expressions on the root sheath of hair follicles were up-regulated in both Sample I and Sample II groups.
5. TGF-β1 expressions on the root sheath of hair follicles were not regulated in Sample I or Sample II groups.
6. VEGF expressions in the surrounding tissues of hair follicles were up-regulated in both Sample I and Sample II groups.
7. iNOS expressions in the surrounding tissues of hair follicles were down-regulated in both Sample I and Sample II groups.
Conclusions : These results suggest that Yonnyuniksoogobon-dan has hair growth-promoting activity and these effects relate to up-regulations of EGF and VEFG expressions and down-regulations of TGF-β1 and iNOS expressions on hair roots.
목차
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (48)
참고문헌 신청
1. [학술지(정기간행물)] - Mori O / 1996 / Effects of transforming growth factor β1 in the hair cycle / J Dermatol 23 : 89 ~ 94
2. [학술지(정기간행물)] - Wollina U / 1996 / Expression of transforming growth factor β isoforms and their receptors during hair growth phases in mice / Histol Histopathol 11 : 431 ~ 436
3. [학술지(정기간행물)] - Lachgar S / 1996 / Vascular endothelial growth factor is an autocrine growth factor for hair dermal papilla cells / J Invest Dermatol 106 (1) : 17 ~ 23
4. [학술지(정기간행물)] - Yano K / 2001 / Control of hair growth and follicle size by VEGF-mediated angiogenesis / J Clin Invest. 107 (4) : 409 ~ 417
5. [학술지(정기간행물)] - Romero-Graillet C / 1997 / Nitric oxide produced by ultraviolet-irradiated keratinocytes stimulates melanogenesis / J Clin Invest 99 : 635 ~ 642
2. [학술지(정기간행물)] - Wollina U / 1996 / Expression of transforming growth factor β isoforms and their receptors during hair growth phases in mice / Histol Histopathol 11 : 431 ~ 436
3. [학술지(정기간행물)] - Lachgar S / 1996 / Vascular endothelial growth factor is an autocrine growth factor for hair dermal papilla cells / J Invest Dermatol 106 (1) : 17 ~ 23
4. [학술지(정기간행물)] - Yano K / 2001 / Control of hair growth and follicle size by VEGF-mediated angiogenesis / J Clin Invest. 107 (4) : 409 ~ 417
5. [학술지(정기간행물)] - Romero-Graillet C / 1997 / Nitric oxide produced by ultraviolet-irradiated keratinocytes stimulates melanogenesis / J Clin Invest 99 : 635 ~ 642
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UCI(KEPA) : I410-ECN-0101-2014-519-000285399