지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives : This study was performed to investigate the anti-obesity effects of Gambi-bang 4 (GBB4) on obesity-induced mice.
Methods: C57BL/6 mice were divided into four groups (normal, high fat diet with control, high fat diet with Reductil, high fat diet with GBB4 extract) and fed for 8 weeks. We observed body weight change, the weight change of the adipocytes in body, total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides, serum leptin level, expression of β3AR and leptin genes in 3T3-L1 adipocytes and adipose tissue, and histological changes of adipose tissue and liver cells.
Results :
1. Compared with the control group, the GBB4 group was significantly lower in body weight, weight of adipocytes, and amount of glucose.
2. The GBB4 group was significantly lower in the amount of total cholesterol, LDL-cholesterol and triglycerides, and HDL-cholesterol compared with the control.
3. Compared with the control group, the GBB4 group was significantly lower in the amount of serum leptin.
4. The GBB4 group was significantly higher in the revelation of β3AR and leptin in 3T3-L1 adipocytes and primary adipose cells compared with the control.
5. Compared with the control group, the GBB4 group was smaller in the size of adipocytes in adipose tissue and the adipose vacuoles in liver tissue were decreased.
Conclusions : These results suggested that GBB4 has inhibitory effects on obesity. GBB4 might be applied in treatment of obesity, so further studies analyzing its effects are needed.
Methods: C57BL/6 mice were divided into four groups (normal, high fat diet with control, high fat diet with Reductil, high fat diet with GBB4 extract) and fed for 8 weeks. We observed body weight change, the weight change of the adipocytes in body, total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides, serum leptin level, expression of β3AR and leptin genes in 3T3-L1 adipocytes and adipose tissue, and histological changes of adipose tissue and liver cells.
Results :
1. Compared with the control group, the GBB4 group was significantly lower in body weight, weight of adipocytes, and amount of glucose.
2. The GBB4 group was significantly lower in the amount of total cholesterol, LDL-cholesterol and triglycerides, and HDL-cholesterol compared with the control.
3. Compared with the control group, the GBB4 group was significantly lower in the amount of serum leptin.
4. The GBB4 group was significantly higher in the revelation of β3AR and leptin in 3T3-L1 adipocytes and primary adipose cells compared with the control.
5. Compared with the control group, the GBB4 group was smaller in the size of adipocytes in adipose tissue and the adipose vacuoles in liver tissue were decreased.
Conclusions : These results suggested that GBB4 has inhibitory effects on obesity. GBB4 might be applied in treatment of obesity, so further studies analyzing its effects are needed.
목차
서론
실험
성적
고찰
결론
참고문헌
참고문헌 (54)
참고문헌 신청
1. [학술지(정기간행물)] - Behme MT. Leptin / 1996 / Product of the obese gene / Nutr Today 31 : 138 ~ 141
2. [학술지(정기간행물)] - Considine RV / 1996 / Serum immunoreactive leptin concentration in normal weight and obese humans / N Engl J Med 334 : 292 ~ 295
3. [학술지(정기간행물)] - Fredrich RC / 1995 / Leptin levels reflect body lipid content in mice, Evidence for diet-induced resistance to leptin action / Nature Med 1 (12) : 1311 ~ 1314
4. [학술지(정기간행물)] - Masuzaki H / 1999 / Augmented expression of the obese gene in the adipose tissue from rats fed high-fat diet / Biochem Biophys 140 : 35 ~ 42
5. [학술지(정기간행물)] - Clement K / 1995 / Genetic variation in the $\beta$-adrenergic recepter and increased capacity to gain weight in patients with morbid obesity / New Engl J med 333 : 352 ~ 354
2. [학술지(정기간행물)] - Considine RV / 1996 / Serum immunoreactive leptin concentration in normal weight and obese humans / N Engl J Med 334 : 292 ~ 295
3. [학술지(정기간행물)] - Fredrich RC / 1995 / Leptin levels reflect body lipid content in mice, Evidence for diet-induced resistance to leptin action / Nature Med 1 (12) : 1311 ~ 1314
4. [학술지(정기간행물)] - Masuzaki H / 1999 / Augmented expression of the obese gene in the adipose tissue from rats fed high-fat diet / Biochem Biophys 140 : 35 ~ 42
5. [학술지(정기간행물)] - Clement K / 1995 / Genetic variation in the $\beta$-adrenergic recepter and increased capacity to gain weight in patients with morbid obesity / New Engl J med 333 : 352 ~ 354
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UCI(KEPA) : I410-ECN-0101-2014-519-000280925