지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objective: This study aimed to evaluate the protective effects of Maekmundong-tang (MMDT) on an elastase-induced COPD model.
Materials and Methods: The extract of MMDT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed.
Results: MMDT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, protein level of Cdk1, and gene expression of TNF-α and IL-1β in A549 cells. MMDT treatment also revealed a protective effect on the elastase-induced COPD mice model. This effect was evidenced via histopathological finding including immunofluorescence stains against elastin, collagen, and caspase 3, and protein level of Cdc2 in lung tissue.
Conclusion: These data suggest that MMDT has pharmaceutical properties on COPD. This study can provide scientific evidence for the efficacy of MMDT for clinical application to patients with COPD.
Materials and Methods: The extract of MMDT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed.
Results: MMDT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, protein level of Cdk1, and gene expression of TNF-α and IL-1β in A549 cells. MMDT treatment also revealed a protective effect on the elastase-induced COPD mice model. This effect was evidenced via histopathological finding including immunofluorescence stains against elastin, collagen, and caspase 3, and protein level of Cdc2 in lung tissue.
Conclusion: These data suggest that MMDT has pharmaceutical properties on COPD. This study can provide scientific evidence for the efficacy of MMDT for clinical application to patients with COPD.
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감사의 말씀
참고문헌
참고문헌 (40)
참고문헌 신청
1. [기타자료] - GOLD / 2008 / Global strategy for th diagnosis, management, and prevention of chronic obstructive pulmonary disease
2. [학술지(정기간행물)] - 유철규 / 2009 / 만성폐쇄성폐질환의 병인과 병태생리 / 대한내과학회지 77 (4) : 383 ~ 400
3. [인터넷자원] - / / Korea National Statistical Office, Republic of Korea / Korea National Statistical Office
4. [인터넷자원] - NHLBI / / NHLBI morbidity and mortality chartbook
5. [학술지(정기간행물)] - Murray CJ / 1997 / Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study / Lancet 349 : 1498 ~ 1504
2. [학술지(정기간행물)] - 유철규 / 2009 / 만성폐쇄성폐질환의 병인과 병태생리 / 대한내과학회지 77 (4) : 383 ~ 400
3. [인터넷자원] - / / Korea National Statistical Office, Republic of Korea / Korea National Statistical Office
4. [인터넷자원] - NHLBI / / NHLBI morbidity and mortality chartbook
5. [학술지(정기간행물)] - Murray CJ / 1997 / Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study / Lancet 349 : 1498 ~ 1504
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UCI(KEPA) : I410-ECN-0101-2014-519-000281215