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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: Palmul-tang (hachimotsu-to in Japanese and bawu-tang in Chinese) is a mixture of eight herbs. It is traditionally used for the treatment of anemia, anorexia, general weakness, and female infertility in China, Japan, and Korea. In this study, we investigated the protective effects of Palmul-tang water extract (PTE) against ethanol-induced acute gastric injury in rats.
Material and Methods: Acute gastric lesions were induced by intragastric administration of 5mL/kg body weight of absolute ethanol to each rat. Control group rats were given PBS orally and the ethanol group (EtOH group) received absolute ethanol (5mL/kg) by oral gavage. The positive control group and the PTE group were given oral doses of omeprazole (50mg/kg) or PTE (400mg/kg), respectively, 2 h prior to the administration of absolute ethanol. The stomach of each animal was excised and examined for gastric mucosal lesions. To confirm the protective effects of PTE, we evaluated the degree of lipid peroxidation, the level of reduced glutathione (GSH), and the activities of the antioxidant enzymes catalase, glutathione-S-transferase, glutathione peroxidase, and glutathione reductase in the stomach.
Results: PTE reduced ethanol-induced hemorrhage and hyperemia in the gastric mucosa. PTE reduced the increase in lipid peroxidation associated with ethanol-induced acute gastric lesions and increased mucosal GSH content and the activities of antioxidant enzymes.
Conclusion: These results indicate that PTE protects gastric mucosa against ethanol-induced acute gastric injury by increasing antioxidant status. We suggest that PTE could be developed as an effective drug for the treatment of acute gastric injury.
Material and Methods: Acute gastric lesions were induced by intragastric administration of 5mL/kg body weight of absolute ethanol to each rat. Control group rats were given PBS orally and the ethanol group (EtOH group) received absolute ethanol (5mL/kg) by oral gavage. The positive control group and the PTE group were given oral doses of omeprazole (50mg/kg) or PTE (400mg/kg), respectively, 2 h prior to the administration of absolute ethanol. The stomach of each animal was excised and examined for gastric mucosal lesions. To confirm the protective effects of PTE, we evaluated the degree of lipid peroxidation, the level of reduced glutathione (GSH), and the activities of the antioxidant enzymes catalase, glutathione-S-transferase, glutathione peroxidase, and glutathione reductase in the stomach.
Results: PTE reduced ethanol-induced hemorrhage and hyperemia in the gastric mucosa. PTE reduced the increase in lipid peroxidation associated with ethanol-induced acute gastric lesions and increased mucosal GSH content and the activities of antioxidant enzymes.
Conclusion: These results indicate that PTE protects gastric mucosa against ethanol-induced acute gastric injury by increasing antioxidant status. We suggest that PTE could be developed as an effective drug for the treatment of acute gastric injury.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (38)
참고문헌 신청
1. [학술지(정기간행물)] - Johansen JS / 2005 / Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice / Cardiovascul Diabetol 4 (1) : 5 ~
2. [학술지(정기간행물)] - Valko, M / 2007 / Free radicals and antioxidants in normal physiological function and human disease / Int J Biochem Cell Biol 39 (1) : 44 ~ 84
3. [학술지(정기간행물)] - Sener-Muratoglu GS / 2001 / Protective effects of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats / Dig Dis. Sci 46 (2) : 318 ~ 330
4. [학술지(정기간행물)] - Suresh MV / 1999 / Impact of massive ascorbic acid supplementation on alcohol induced oxidative stress in guinea pigs / Toxicol let 104 (3) : 221 ~ 229
5. [학술지(정기간행물)] - Sugimoto N / 2000 / Effect of vitamin E on aspirin-induced gastric mucosal injury in rats / Dig Dis Sci 45 (3) : 599 ~ 605
2. [학술지(정기간행물)] - Valko, M / 2007 / Free radicals and antioxidants in normal physiological function and human disease / Int J Biochem Cell Biol 39 (1) : 44 ~ 84
3. [학술지(정기간행물)] - Sener-Muratoglu GS / 2001 / Protective effects of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats / Dig Dis. Sci 46 (2) : 318 ~ 330
4. [학술지(정기간행물)] - Suresh MV / 1999 / Impact of massive ascorbic acid supplementation on alcohol induced oxidative stress in guinea pigs / Toxicol let 104 (3) : 221 ~ 229
5. [학술지(정기간행물)] - Sugimoto N / 2000 / Effect of vitamin E on aspirin-induced gastric mucosal injury in rats / Dig Dis Sci 45 (3) : 599 ~ 605
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UCI(KEPA) : I410-ECN-0101-2014-519-000273115