지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: Brain edema is brain swelling that occurs due to the accumulation of excess water in the brain parenchyma. AQP4 and AQP9 are water-channel proteins expressed strongly in the brain and control water fluxes into and out of the brain parenchyma. This study was conducted to evaluate effect of Hwangnyeonhaedok-tang on brain edema and intracerebral hemorrhage.
Methods: Intracerebral hemorrhage was induced by intrastriatal injection of type Ⅳ collagenase(0.23 U/㎕, 0.1 ㎕/min) into Sprague-Dawley rat brains. Hwangnyeonhaedok-tang water extract(1,000 ㎎/㎏) was administered orally three times every 20 hours from 4 hours after ICH operation. Then hematoma volume, brain edema percentage, and water content of brain tissue were measured. Immuno-histochemistry was performed for AQP4 and AQP9 expressions in the brain sections and area % of immuno-labeling was analyzed with image analyzing system.
Results:
1. Water extract of Hwangnyeonhaedok-tang reduced hematoma volume of ICH induced rat.
2. Water extract of Hwangnyeonhaedok-tang reduced MPO positive neutrophils in the perihematoma of the ICH induced rat.
3. Water extract of Hwangnyeonhaedok-tang reduced brain edema percentage and water content of brain tissue of ICH induced rat.
4. Water extract of Hwangnyeonhaedok-tang reduced AQP4 immuno-positive cells in the perihematoma of the ICH induced rat.
5. Water extract of Hwangnyeonhaedok-tang reduced AQP9 immuno-positive cells in the perihematoma of the ICH induced rat.
Conclusions: These results suggest that Hwangnyeonhaedok-tang decreases intracerebral hemorrhage and brain edema by means of downregulating AQP4 and AQP9 expressions in the brain.
Methods: Intracerebral hemorrhage was induced by intrastriatal injection of type Ⅳ collagenase(0.23 U/㎕, 0.1 ㎕/min) into Sprague-Dawley rat brains. Hwangnyeonhaedok-tang water extract(1,000 ㎎/㎏) was administered orally three times every 20 hours from 4 hours after ICH operation. Then hematoma volume, brain edema percentage, and water content of brain tissue were measured. Immuno-histochemistry was performed for AQP4 and AQP9 expressions in the brain sections and area % of immuno-labeling was analyzed with image analyzing system.
Results:
1. Water extract of Hwangnyeonhaedok-tang reduced hematoma volume of ICH induced rat.
2. Water extract of Hwangnyeonhaedok-tang reduced MPO positive neutrophils in the perihematoma of the ICH induced rat.
3. Water extract of Hwangnyeonhaedok-tang reduced brain edema percentage and water content of brain tissue of ICH induced rat.
4. Water extract of Hwangnyeonhaedok-tang reduced AQP4 immuno-positive cells in the perihematoma of the ICH induced rat.
5. Water extract of Hwangnyeonhaedok-tang reduced AQP9 immuno-positive cells in the perihematoma of the ICH induced rat.
Conclusions: These results suggest that Hwangnyeonhaedok-tang decreases intracerebral hemorrhage and brain edema by means of downregulating AQP4 and AQP9 expressions in the brain.
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결과
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참고문헌
참고문헌 (35)
참고문헌 신청
1. [학술지(정기간행물)] - Klatzo I / 1994 / Evolution of brain edema / Acta Neurochir suppl(Wien) 60 : 3 ~ 6
2. [학술지(정기간행물)] - Sung JH / 2008 / Intracerebral and Subarachnoid Hemorrhage; Decision Points in Neurovascular Critical Care / J Neurocrit Care 1 : 65 ~ 72
3. [학술지(정기간행물)] - Papadopoulos MC / 2007 / Aquaporin-4 and brain edema / Pediatr Nephrol 22 : 778 ~ 784
4. [학술지(정기간행물)] - 조기현 / 2003 / 뇌출혈의 내과적 치료 / 대한뇌졸중학회지 5 (1) : 26 ~ 29
5. [학술지(정기간행물)] - Xi G / 2002 / Pathophysiology of brain edema formation / Neurosurg Clin N Am 13 : 371 ~ 383
2. [학술지(정기간행물)] - Sung JH / 2008 / Intracerebral and Subarachnoid Hemorrhage; Decision Points in Neurovascular Critical Care / J Neurocrit Care 1 : 65 ~ 72
3. [학술지(정기간행물)] - Papadopoulos MC / 2007 / Aquaporin-4 and brain edema / Pediatr Nephrol 22 : 778 ~ 784
4. [학술지(정기간행물)] - 조기현 / 2003 / 뇌출혈의 내과적 치료 / 대한뇌졸중학회지 5 (1) : 26 ~ 29
5. [학술지(정기간행물)] - Xi G / 2002 / Pathophysiology of brain edema formation / Neurosurg Clin N Am 13 : 371 ~ 383
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UCI(KEPA) : I410-ECN-0101-2014-519-000262347