지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives : Cocaine has been well known as a representative drug of abuse for its strong reinforcing effect linked to the mesolimbic reward system including dopamine, and such reinforcement leads to the addiction. Acupuncture has been used widely in eastern Asia for the treatment of various diseases including mental disorders and psychiatric problems, and is gathering more interest as one of the complementary and alternative medicines in western countries. In a previous study, we demonstrated that acupuncture at HT7 could affect dopamine release in the mesolimbic system of rats sensitized to alcohol and morphine. This study was designed to investigate whether acupuncture at HT7 could attenuate cocaine intake or not.
Material & Methods : Male Sprague-Dawley rats weighing 270-300 g at the start of experiment were trained to self-administer food pellets under a fixed ratio 1 schedule. After the success of acquisition of 100 pellets within 3 h for 3 consecutive days, animals were subjected to surgery whereby Silastic tubing was implanted into right jugular vein and secured with mesh under the anesthetization using pentobarbital injection (50 mg/kg, i.p.). Following recovery, rats were trained to self-administer cocaine (0.25 mg/kg) in daily 2 h sessions under fixed ratio 1 schedule over 10 days. Each treatment was performed on the next day of each establishment of baseline.
Results : Results show that acupuncture at HT7, but not at control points, reduced cocaine intake significantly. Acupuncture at HT7 decreased selectively active lever response from 63.15 ± 3.35 to 51.46 ± 3.99 corresponding 82.12 ± 5.31% compared to basal level. Also, it was demonstrated that the effect of acupuncture was mainly occurred at the half period. Nevertheless, acupuncture at HT7 did not influence the food taking behavior.
Conclusions : From the results of this study, it may be suggested that acupuncture at HT7, at least in part, could contribute to the treatment of cocaine abuse.
Material & Methods : Male Sprague-Dawley rats weighing 270-300 g at the start of experiment were trained to self-administer food pellets under a fixed ratio 1 schedule. After the success of acquisition of 100 pellets within 3 h for 3 consecutive days, animals were subjected to surgery whereby Silastic tubing was implanted into right jugular vein and secured with mesh under the anesthetization using pentobarbital injection (50 mg/kg, i.p.). Following recovery, rats were trained to self-administer cocaine (0.25 mg/kg) in daily 2 h sessions under fixed ratio 1 schedule over 10 days. Each treatment was performed on the next day of each establishment of baseline.
Results : Results show that acupuncture at HT7, but not at control points, reduced cocaine intake significantly. Acupuncture at HT7 decreased selectively active lever response from 63.15 ± 3.35 to 51.46 ± 3.99 corresponding 82.12 ± 5.31% compared to basal level. Also, it was demonstrated that the effect of acupuncture was mainly occurred at the half period. Nevertheless, acupuncture at HT7 did not influence the food taking behavior.
Conclusions : From the results of this study, it may be suggested that acupuncture at HT7, at least in part, could contribute to the treatment of cocaine abuse.
목차
Introduction
Materials and Methods
Results
Discussion
Conclusion
References
참고문헌 (25)
참고문헌 신청
1. [학술지(정기간행물)] - Hammer RP / 1997 / Neural mechanisms of tolerance to the effects of cocaine / Behav Brain Res 84 (1) : 225 ~ 239
2. [학술지(정기간행물)] - Kalivas PW / 2004 / Glutamate system in cocaine addiction / Current Opinion in Pharmacol 4 : 23 ~ 29
3. [학술지(정기간행물)] - Dackis CA / 2001 / Cocaine dependence: a disease of the brain's reward centers / J Subst Abuse Treat 21 (3) : 111 ~ 1117
4. [학술지(정기간행물)] - Egilmez Y / 1995 / Dopamine release during cocaine self-administration in rats: effect of SCH23390 / Brain Res 701 (1) : 142 ~ 150
5. [학술지(정기간행물)] - Di Chiara G / 1988 / Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats / Proc Natl Acad Sci USA 85 (14) : 5274 ~ 5278
2. [학술지(정기간행물)] - Kalivas PW / 2004 / Glutamate system in cocaine addiction / Current Opinion in Pharmacol 4 : 23 ~ 29
3. [학술지(정기간행물)] - Dackis CA / 2001 / Cocaine dependence: a disease of the brain's reward centers / J Subst Abuse Treat 21 (3) : 111 ~ 1117
4. [학술지(정기간행물)] - Egilmez Y / 1995 / Dopamine release during cocaine self-administration in rats: effect of SCH23390 / Brain Res 701 (1) : 142 ~ 150
5. [학술지(정기간행물)] - Di Chiara G / 1988 / Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats / Proc Natl Acad Sci USA 85 (14) : 5274 ~ 5278
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UCI(KEPA) : I410-ECN-0101-2014-519-000262418