지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.2
- 수록면
- 85 - 92 (8page)
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초록· 키워드
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IL-23 and IL-12 are structurally similar and critical for the generation of efficient cellular immune responses. Toxoplasma gondii induces a strong cell-mediated immune response. However, little is known about IL-23 secretion profiles in T. gondii-infected immune cells in connection with IL-12. We compared the patterns of IL-23 and IL-12 production by THP-1 human monocytic cells in response to stimulation with live or heat-killed T. gondii tachyzoites, or with equivalent quantities of either T. gondii excretory/secretory proteins (ESP) or soluble tachyzoite antigen (STAg). IL-23 and IL-12 were significantly increased from 6 hr after stimulation with T. gondii antigens, and their secretions were increased with parasite dose-dependent manner. IL-23 concentrations were significantly higher than those of IL-12 at the same multiplicity of infection. IL-23 secretion induced by live parasites was significantly higher than that by heat-killed parasites, ESP, or STAg, whereas IL-12 secretion by live parasite was similar to those of ESP or STAg. However, the lowest levels of both cytokines were at stimulation with heat-killed parasites. These data indicate that IL-23 secretion patterns by stimulation with various kinds of T. gondii antigens at THP-1 monocytic cells are similar to those of IL-12, even though the levels of IL-23 induction were significantly higher than those of IL-12. The detailed kinetics induced by each T. gondii antigen were different from each other.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (17)
참고문헌 신청
1. [학술지(정기간행물)] - Tenter AM / 2000 / Toxoplasma gondii: from animals to humans / Int J Parasitol 30 : 1217 ~ 1258
2. [학술지(정기간행물)] - Miller CM / 2009 / The immunobiology of the innate response to Toxoplasma gondii / Int J Parasitol 39 : 23 ~ 39
3. [학술지(정기간행물)] - Langrish CL / 2004 / IL-12 and IL-23: master regulators of innate and adaptive immunity / Immunol Rev 202 : 96 ~ 105
4. [학술지(정기간행물)] - Bliss SK / 1999 / Human polymorphonuclear leukocytes produce IL-12, TNF-α, and the chemokines macrophage-inflammatory protein-1α and -1β in response to Toxoplasma gondii antigens / J Immunol 162 : 7369 ~ 7375
5. [학술지(정기간행물)] - Robben PM / 2004 / Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype / J Immunol 172 : 3686 ~ 3694
2. [학술지(정기간행물)] - Miller CM / 2009 / The immunobiology of the innate response to Toxoplasma gondii / Int J Parasitol 39 : 23 ~ 39
3. [학술지(정기간행물)] - Langrish CL / 2004 / IL-12 and IL-23: master regulators of innate and adaptive immunity / Immunol Rev 202 : 96 ~ 105
4. [학술지(정기간행물)] - Bliss SK / 1999 / Human polymorphonuclear leukocytes produce IL-12, TNF-α, and the chemokines macrophage-inflammatory protein-1α and -1β in response to Toxoplasma gondii antigens / J Immunol 162 : 7369 ~ 7375
5. [학술지(정기간행물)] - Robben PM / 2004 / Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype / J Immunol 172 : 3686 ~ 3694
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UCI(KEPA) : I410-ECN-0101-2014-510-002535726