Potential Correlation between Carboxylic Acid Metabolites in Biomphalaria alexandrina Snails after Exposure to Schistosoma mansoni Infection

Salwa M. F. Abou Elseoud; Nashwa S. Abdel Fattah; Hayam M. Ezz El Din; Hala Abdel Al; Hanan Mossalem; Noha Elleboudy

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자료유형: 학술저널

저자정보: Salwa M. F. Abou Elseoud (Ain Shams University) Nashwa S. Abdel Fattah (Ain Shams University) Hayam M. Ezz El Din (Ain Shams University) Hala Abdel Al (Ain Shams University) Hanan Mossalem (Theodor Bilharz Research Institute) Noha Elleboudy (Ain Shams University)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.50 No.2

발행연도: 2012.6

수록면: 119 - 126 (8page)

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Carboxylic acids play an important role in both aerobic and anaerobic metabolic pathways of both the snail and the parasite. Monitoring the effects of infection by schistosome on Biomphalaria alexandrina carboxylic acids metabolic profiles represents a promising additional source of information about the state of metabolic system. We separated and quantified pyruvic, fumaric, malic, oxalic, and acetic acids using ion-suppression reversed-phase high performance liquid chromatography (HPLC) to detect correlations between these acids in both hemolymph and digestive gland gonad complex (DGG’s) samples in a total of 300 B. alexandrina snails (150 infected and 150 controls) at different stages of infection. The results showed that the majority of metabolite pairs did not show significant correlations. However, some high correlations were found between the studied acids within the control group but not in other groups. More striking was the existence of reversed correlations between the same acids at different stages of infection. Some possible explanations of the underlying mechanisms were discussed. Ultimately, however, further data are required for resolving the responsible regulatory events. These findings highlight the potential of metabolomics as a novel approach for fundamental investigations of host-pathogen interactions as well as disease surveillance and control.

#Schistosoma mansoni #Biomphalaria alexandrina #carboxylic acid #chromatography

참고문헌 (23)

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