지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 291 - 294 (4page)
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초록· 키워드
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Trichomonas vaginalis is a flagellated lumen-dwelling extracellular protozoan parasite that causes human trichomoniasis via sexual intercourse. Human neutrophils play a crucial role in acute tissue inflammatory responses in T. vaginalis infection. In this study, we investigated the signaling mechanism of neutrophil responses when stimulated with T. vaginalis-derived secretory products (TvSP), which were collected from 1×107 live trichomonads. Incubation of human neutrophils isolated from peripheral blood with TvSP induced up-regulation of IL-8 protein secretion. In addition, stimulation with TvSP induced phosphorylation of NF-κB and CREB in neutrophils. Moreover, TvSP-induced IL-8 production was also significantly inhibited by pretreatment of neutrophils with iκB inhibitor or CREB inhibitor. These results suggest that transcription factors NF-κB and CREB are involved in IL-8 production in human neutrophils induced by stimulation with T. vaginalis infection.
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등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
1. [학술지(정기간행물)] - Fouts AC / 1980 / Trichomonas vaginalis: Reevaluation of its clinical presentation and laboratory diagnosis / J Infect Dis 141 : 137 ~ 143
2. [학술지(정기간행물)] - Brill JR / 2010 / Diagnosis and treatment of urethritis in men / Am Fam Physician 81 : 873 ~ 878
3. [보고서] - World Health Organization / 1995 / An overview of selected curable sexually transmitted diseases. Global Programme on AIDS Report
4. [학술지(정기간행물)] - Landers DV / 2004 / P dictive value of the clinical diagnosis of lower genital tract infection in women / Am J Obstet Gynecol 190 : 1004 ~ 1010
5. [학술지(정기간행물)] - Shaio MF / 1995 / Influence of humoral immunity on leukotriene B4 production by neutrophils in response to Trichomonas vaginalis stimulation / Parasite Immunol 17 : 127 ~ 133
2. [학술지(정기간행물)] - Brill JR / 2010 / Diagnosis and treatment of urethritis in men / Am Fam Physician 81 : 873 ~ 878
3. [보고서] - World Health Organization / 1995 / An overview of selected curable sexually transmitted diseases. Global Programme on AIDS Report
4. [학술지(정기간행물)] - Landers DV / 2004 / P dictive value of the clinical diagnosis of lower genital tract infection in women / Am J Obstet Gynecol 190 : 1004 ~ 1010
5. [학술지(정기간행물)] - Shaio MF / 1995 / Influence of humoral immunity on leukotriene B4 production by neutrophils in response to Trichomonas vaginalis stimulation / Parasite Immunol 17 : 127 ~ 133
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UCI(KEPA) : I410-ECN-0101-2014-510-002511439