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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 303 - 308 (6page)
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초록· 키워드
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This study investigated whether elevated host immune capacity can inhibit T. gondii infection. For this purpose, we used silk protein extracted from Bombyx mori cocoons as a natural supplement to augment immune capacity. After silk protein administration to BALB/c mice for 6 weeks, ratios of T lymphocytes (CD4+ and CD8+ T-cells) and splenocyte proliferative capacities in response to Con A or T. gondii lysate antigen (TLA) were increased. Of various cytokines, which regulate immune systems, Th1 cytokines, such as IFN-γ, IL-2, and IL-12, were obviously increased in splenocyte primary cell cultures. Furthermore, the survival of T. gondii (RH strain)-infected mice increased from 2 days to 5 or more days. In a state of immunosuppression induced by methylprednisolone acetate, silk protein-administered mice were resistant to reduction in T-lymphocyte (CD4+ and CD8+ T-cells) numbers and the splenocyte proliferative capacity induced by Con A or TLA with a statistical significance. Taken together, our results suggest that silk protein augments immune capacity in mice and the increased cellular immunity by silk protein administration increases host protection against acute T. gondii infection.
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참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Teramoto H / 2008 / Preparation of gel film from Bombyx mori silk sericin and its characterization as a wound dressing / Biosci Biotechnol Biochem 72 : 3189 ~ 3196
2. [학술지(정기간행물)] - Padamwar MN / 2005 / Silk sericin as a moisturizer: An in vivo study / J Cosmet Dermatol 4 : 250 ~ 257
3. [학술지(정기간행물)] - Altman GH / 2003 / Silk-based biomaterials / Biomaterials 24 : 401 ~ 416
4. [학술지(정기간행물)] - Li YG / 2008 / Protective effects of sericin protein on alcohol-mediated liver damage in mice / Alcohol Alcoholism 43 : 246 ~ 253
5. [학술지(정기간행물)] - Jung EY / 2010 / Feeding silk protein hydrolysates to C57BL/KsJ-db/db mice improves blood glucose and lipid profiles / Nutr. Res. 30 : 783 ~ 790
2. [학술지(정기간행물)] - Padamwar MN / 2005 / Silk sericin as a moisturizer: An in vivo study / J Cosmet Dermatol 4 : 250 ~ 257
3. [학술지(정기간행물)] - Altman GH / 2003 / Silk-based biomaterials / Biomaterials 24 : 401 ~ 416
4. [학술지(정기간행물)] - Li YG / 2008 / Protective effects of sericin protein on alcohol-mediated liver damage in mice / Alcohol Alcoholism 43 : 246 ~ 253
5. [학술지(정기간행물)] - Jung EY / 2010 / Feeding silk protein hydrolysates to C57BL/KsJ-db/db mice improves blood glucose and lipid profiles / Nutr. Res. 30 : 783 ~ 790
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UCI(KEPA) : I410-ECN-0101-2014-510-002511464