지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 33 - 38 (6page)
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초록· 키워드
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Prompt and accurate diagnosis of malaria is the key to prevent disease morbidity and mortality. This study was carried out to evaluate diagnostic performance of 3 commercial rapid detection tests (RDTs), i.e., Malaria Antigen Pf/PanTM, Malaria Ag-PfTM, and Malaria Ag-PvTM tests, in comparison with the microscopic and PCR methods. A total of 460 blood samples microscopically positive for Plasmodium falciparum (211 samples), P. vivax (218), mixed with P. falciparum and P. vivax (30), or P. ovale (1), and 124 samples of healthy subjects or patients with other fever-related infections, were collected. The sensitivities of Malaria Ag-PfTM and Malaria Antigen Pf/PanTM compared with the microscopic method for P. falciparum or P. vivax detection were 97.6% and 99.0%, or 98.6% and 99.0%, respectively. The specificities of Malaria Ag-PfTM, Malaria Ag-PvTM, and Malaria Antigen Pf/PanTM were 93.3%, 98.8%, and 94.4%, respectively. The sensitivities of Malaria Ag-PfTM, Malaria Antigen Pf/PanTM, and microscopic method, when PCR was used as a reference method for P. falciparum or P. vivax detection were 91.8%, 100%, and 96.7%, or 91.9%, 92.6%, and 97.3%, respectively. The specificities of Malaria Ag-PfTM, Malaria Ag-PvTM, Malaria Antigen Pf/PanTM, and microscopic method were 66.2%, 92.7%, 73.9%, and 78.2%, respectively. Results indicated that the diagnostic performances of all the commercial RDTs are satisfactory for application to malaria diagnosis.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (34)
참고문헌 신청
1. [학술지(정기간행물)] - Clark IA / 2004 / Pathogenesis of malaria and clinically similar conditions / Clin Microbiol Rev 17 : 509 ~ 539
2. [학술지(정기간행물)] - Na-Bangchang K / 2009 / Current status of malaria chemotherapy and the role of pharmacology in antimalarial drug research and developmen / Fundam Clin Pharmacol 23 : 387 ~ 409
3. [학술지(정기간행물)] - Moody A / 2002 / Rapid diagnostic tests for malaria parasites / Clin Microbiol Rev 15 : 66 ~ 78
4. [학술지(정기간행물)] - Bacon DJ / 2007 / World Antimalarial Resistance Network (WARN) II: in vitro antimalarial drug susceptibility / Malar J 6 : 120 ~
5. [학술지(정기간행물)] - Demirev PA / 1980 / Detection of malaria parasites in blood by laser desorption mass spectrometry. Anal Chem 2002; 74: 3262-3266. 6. Draper CC, Sirr SS. Serological investigations in retrospective diagnosis of malaria / Br Med J 280 : 1575 ~ 1576
2. [학술지(정기간행물)] - Na-Bangchang K / 2009 / Current status of malaria chemotherapy and the role of pharmacology in antimalarial drug research and developmen / Fundam Clin Pharmacol 23 : 387 ~ 409
3. [학술지(정기간행물)] - Moody A / 2002 / Rapid diagnostic tests for malaria parasites / Clin Microbiol Rev 15 : 66 ~ 78
4. [학술지(정기간행물)] - Bacon DJ / 2007 / World Antimalarial Resistance Network (WARN) II: in vitro antimalarial drug susceptibility / Malar J 6 : 120 ~
5. [학술지(정기간행물)] - Demirev PA / 1980 / Detection of malaria parasites in blood by laser desorption mass spectrometry. Anal Chem 2002; 74: 3262-3266. 6. Draper CC, Sirr SS. Serological investigations in retrospective diagnosis of malaria / Br Med J 280 : 1575 ~ 1576
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UCI(KEPA) : I410-ECN-0101-2014-510-002511757