지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.7
- 수록면
- 273 - 282 (10page)
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초록· 키워드
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The present study was designed to investigate the cardioprotective effects of Korean Red Ginseng extract (KRG) on isoproterenol (ISO)-induced cardiac injury in rats, particularly in regards to electrocardiographic changes, hemodynamics, cardiac function, serum cardiac enzymes, components of the myocardial antioxidant defense system, as well as inflammatory markers and histopathological changes in heart tissue. ISO (150 mg/kg, subcutaneous, two doses administered at 24-hour intervals) treatment induced significant decreases in P waves and QRS complexes (p<0.01), as well as a significant increase in ST segments. Moreover, ISO-treated rats exhibited decreases in left-ventricular systolic pressure, maximal rate of developed left ventricular pressure (+dP/dtmax) and minimal rate of developed left ventricular pressure (?dP/dtmax), in addition to significant increases in lactate dehydrogenase, aspartate transaminase, alanine transaminase and creatine kinase activity. Heart rate, however, was not significantly altered. And the activities of superoxide dismutase, catalase and glutathione peroxidase were decreased, whereas the activity of malondialdehyde was increased in the ISO-treated group. ISO-treated group also showed increased caspase-3 level, release of inflammatory markers and neutrophil infiltration in heart tissue. KRG pretreatment (250 and 500 mg/kg, respectively) significantly ameliorated almost all of the parameters of heart failure and myocardial injury induced by ISO. The protective effect of KRG on ISO-induced cardiac injury was further confirmed by histopathological study. In this regard, ISO treatment induced fewer morphological changes in rats pretreated with 250 or 500 mg/kg of KRG. Compared with the control group, all indexes in rats administered KRG (500 mg/kg) alone were unaltered (p>0.05). Our results suggest that KRG significantly protects against cardiac injury and ISO-induced cardiac infarction by bolstering antioxidant action in myocardial tissue.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (40)
참고문헌 신청
1. [학술지(정기간행물)] - Kumar JS / 1992 / Changes in levels of lipid peroxides and activity of superoxide dismutase and catalase in diabetes associated with myocardial infarction / Indian J Exp Biol 30 : 122 ~ 127
2. [학술지(정기간행물)] - Aronow WS. / 2006 / Epidemiology, pathophysiology, prognosis, and treatment of systolic and diastolic heart failure / Cardiol Rev 14 : 108 ~ 124
3. [학술지(정기간행물)] - Lopez AD / 1998 / The global burden of disease, 1990-2020 / Nat Med 4 : 1241 ~ 1243
4. [학술지(정기간행물)] - Cai Q / 1997 / Dietary flavonoids, quercetin, luteolin and genistein, reduce oxidative DNA damage and lipid peroxidation and quench free radicals / Cancer Lett 119 : 99 ~ 107
5. [학술지(정기간행물)] - Dikshit M / 1992 / Free radical scavenger mechanisms in experimentally induced ischemia in the rabbit heart and protective effect of verapamil / Arch Int Pharmacodyn Ther 318 : 55 ~ 65
2. [학술지(정기간행물)] - Aronow WS. / 2006 / Epidemiology, pathophysiology, prognosis, and treatment of systolic and diastolic heart failure / Cardiol Rev 14 : 108 ~ 124
3. [학술지(정기간행물)] - Lopez AD / 1998 / The global burden of disease, 1990-2020 / Nat Med 4 : 1241 ~ 1243
4. [학술지(정기간행물)] - Cai Q / 1997 / Dietary flavonoids, quercetin, luteolin and genistein, reduce oxidative DNA damage and lipid peroxidation and quench free radicals / Cancer Lett 119 : 99 ~ 107
5. [학술지(정기간행물)] - Dikshit M / 1992 / Free radical scavenger mechanisms in experimentally induced ischemia in the rabbit heart and protective effect of verapamil / Arch Int Pharmacodyn Ther 318 : 55 ~ 65
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UCI(KEPA) : I410-ECN-0101-2014-520-002962118