지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.8
- 수록면
- 421 - 426 (6page)
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초록· 키워드
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Several studies have shown the mechanisms and importance of immune responses against Toxoplasma gondii infection and the notable role of cholinesterases in inflammatory reactions. However, the association between those factors has not yet been investigated. Therefore, the aim of this study was to evaluate the acetylcholinesterase (AChE) activity in blood and lymphocytes and the activity of butyrylcholinesterase (BChE) in serum of rats experimentally infected with T. gondii during the acute phase of infection. For that, an in vivo study was performed with evaluations of AChE and BChE activities on days 5 and 10 post-infection (PI). The activity of AChE in blood was increased on day 5 PI, while in lymphocytes its activity was enhanced on days 5 and 10 PI (P<0.05). No significant difference was observed between groups regarding to the activity of BChE in serum. A positive (P<0.01) correlation was observed between AChE activity and number of lymphocytes. The role of AChE as an inflammatory marker is well known in different pathologies; thus, our results lead to the hypothesis that AChE has an important role in modulation of early immune responses against T. gondii infection.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (25)
참고문헌 신청
Dubey JP / 2007 / Toxoplasma gondii, the Model Apicomplexan: Perspectives and Methods / Academic Press :1~17
Montoya JG / 2004 / Toxoplasmosis / Lancet 363:1965~1976
Tracey KJ / 2002 / The inflammatory reflex / Nature 420:853~859
Miller CM / 2009 / The immunobiology of the innate response to Toxoplasma gondii / Int J Parasitol 39:23~39
Da Silva AS / 2011 / Trypanosoma evansi : Immune response and acetylcholinesterase activity in lymphocytes from infected rats / Exp Parasitol 127:475~480
Montoya JG / 2004 / Toxoplasmosis / Lancet 363:1965~1976
Tracey KJ / 2002 / The inflammatory reflex / Nature 420:853~859
Miller CM / 2009 / The immunobiology of the innate response to Toxoplasma gondii / Int J Parasitol 39:23~39
Da Silva AS / 2011 / Trypanosoma evansi : Immune response and acetylcholinesterase activity in lymphocytes from infected rats / Exp Parasitol 127:475~480
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UCI(KEPA) : I410-ECN-0101-2014-510-002788861