지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.10
- 수록면
- 442 - 450 (9page)
이용수
초록· 키워드
오류제보하기
The aim of this study was to determine and compare the preventive effect of Korean White Ginseng and Red Ginseng on oxidative stress in H₂O₂-treated HepG2 cells. The roots of ginseng were extracted with 70% methanol and partitioned with butanol to obtain saponin fractions, which have been known as bioactive constituents of ginseng. 2′,7′-Dichlorofluorescein diacetate (DCF-DA) assay and malondialdehyde (MDA) content were measured for evaluating intracellular reactive oxygen species (ROS) generation. Also, mRNA expressions and activities of antioxidant enzymes were analyzed to determine the antioxidant activity of saponin or non-saponin fractions of ginsengs. According to DCF-DA assay, H₂O₂-induced MDA release and ROS generation were significantly reduced by treatment with saponin fractions of white and red ginseng roots. Also, saponin fractions increased effectively intracellular antioxidant enzyme activities including catalase, glutathione peroxidase and superoxide dismutase in H₂O₂-treated HepG2 hepatoma cells. In general, red ginseng was more effective than white ginseng for reducing oxidative stress. These results indicate that administration of red ginseng may certainly contribute relatively stronger than white ginseng to prevent from damaging liver function by oxidative stress.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Ray PD / 2012 / Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling / Cell Signal 24 : 981 ~ 990
2. [학술지(정기간행물)] - Droge W. / 2002 / Free radicals in the physiological control of cell function / Physiol Rev 82 : 47 ~ 95
3. [학술지(정기간행물)] - Mari M / 2010 / Redox control of liver function in health and disease / Antioxid Redox Signal 12 : 1295 ~ 1331
4. [학술지(정기간행물)] - Jaeschke H / 2002 / Mechanisms of hepatotoxicity / Toxicol Sci 65 : 166 ~ 176
5. [학술지(정기간행물)] - Kang KS / 2006 / Study on the nitric oxide scavenging effects of ginseng and its compounds / J Agric Food Chem 54 : 2558 ~ 2562
2. [학술지(정기간행물)] - Droge W. / 2002 / Free radicals in the physiological control of cell function / Physiol Rev 82 : 47 ~ 95
3. [학술지(정기간행물)] - Mari M / 2010 / Redox control of liver function in health and disease / Antioxid Redox Signal 12 : 1295 ~ 1331
4. [학술지(정기간행물)] - Jaeschke H / 2002 / Mechanisms of hepatotoxicity / Toxicol Sci 65 : 166 ~ 176
5. [학술지(정기간행물)] - Kang KS / 2006 / Study on the nitric oxide scavenging effects of ginseng and its compounds / J Agric Food Chem 54 : 2558 ~ 2562
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-520-002777931