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    초록·키워드

    Background : Cardiac hypertrophy is an independent risk factor for cerebrovascular event. However, the cellular mechanisms involved in cerebrovascular impairment during cardiac hypertrophy are unknown. Of the many vasoactive agonists that have been implicated in vascular hyperresponsiveness in cardiac hypertrophy, angiotensin II (Ang II) appears to play one of the important roles. Methods and results : To clarify the correlation between intracellular Ca²⁺ dynamics by Ang II and level of related proteins, we monitored cytoplasmic Ca²⁺ concentration ([Ca²⁺]i)by fura-2 AM, flou-4 AM ratio and analyzed expression of Ang II by real-time RT-PCR, western blotting in cerebral artery during cardiac hypertrophy. Basal [Ca²⁺]i were higher in ... 전체 초록 보기

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