지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 5 - 12 (8page)
이용수
초록· 키워드
오류제보하기
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor arising in the stomach, which is characterized by the protein-tyrosine kinase KIT (CD117) expression. Historically, surgical resection has been the mainstay of the curative treatment for localized primary tumors. However, more than an half of the patients with GISTs subsequently develop recurrence or metastasis. The discovery of the molecular pathogenesis of GIST led to the remarkable development of the molecular-targeted therapy with imatinib mesylate, a specific tyrosine kinase inhibitor, and the clinical management of GISTs has rapidly evolved during the last decade. As imatinib has demonstrated significant response in most metastatic GIST, it became the standard first line treatment in patients with metastatic or unresectable GISTs. Nonetheless, treating GIST with a single agent alone is proven to have many limitations because of development of imatinib resistance. Surgical resection still remains the only chance for a cure in GIST treatment. A key strategy for prolonging the survival of patients with GIST is to improve the outcome of surgery. Imatinib use in the GIST management may contribute to surgeons’ success in attaining this objective. It is clear that GIST is a complex disease, and a multidisciplinary approach with effective integration of surgery and targeted therapy is crucial to offer a better prognosis to the patients.
목차
INTRODUCTION
EPIDEMIOLOGY AND CLINICAL PRESENTATION
DIAGNOSIS
PROGNOSIS
TREATMENT
POSTOPERATIVE SURVEILLENCE
CONCLUSION
REFERENCES
참고문헌 (0)
참고문헌 신청이 논문의 저자 정보
이 논문과 함께 이용한 논문
위장관간질종양(GIST)에서 imatinib mesylate를 이용한 표적 치료
이혁준
,
양한광
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2005
.12
A Case of Liver Metastasis of Gastrointestinal Stromal Tumor That Was Resected after Treatment with Imatinib Mesylate and Sunitinib
Gum O Jung
,
Kwon Mook Chae
,
Dong Eun Pa
외 5명
Annals of Hepato-Biliary-Pancreatic Surgery
2010
.12
최근 본 자료
댓글(0)
0