STAT6 Expression and IL-13 Production in Association with Goblet Cell Hyperplasia and Worm Expulsion of Gymnophalloides seoi from C57BL/6 Mice

Jin-Joo Lee; Donghee Kim; Kyoung-Ho Pyo; Min-Ki Kim; Hyo-Jin Kim; Jong-Yil Chai; Eun-Hee Shin

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자료유형: 학술저널

저자정보: Jin-Joo Lee (Seoul National University College of Medicine) Donghee Kim (Seoul National University Gang-Nam Hospital) Kyoung-Ho Pyo (Seoul National University College of Medicine) Min-Ki Kim (Seoul National University College of Medicine) Hyo-Jin Kim (Seoul National University College of Medicine) Jong-Yil Chai (Seoul National University College of Medicine) Eun-Hee Shin (Seoul National University College of Medicine)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.51 No.5

발행연도: 2013.10

수록면: 589 - 594 (6page)

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In intestinal helminth infections, Th2 immune respones are generally associated with mucin secretion for worm expulsion from the host intestine. In particular, IL-4 and IL-13 are the important cytokines related with intestinal mucus production via STAT6 signalling in nematode infections. However, this perspective has never been studied in Gymnophalloides seoi infection. The present study aimed to observe the STAT6 signalling and cytokine responses in C57BL/6 mice, a mouse strain resistant to infection with this trematode. The results showed that worm expulsion occurred actively during days 1-2 post-infection (PI), when goblet cells began to proliferate in the small intestine. The STAT6 gene expression in the mouse spleen became remarkable from day 2 PI. Moreover, G. seoi infection induced a significant increase of IL-13 from day 4 PI in the spleen of infected mice. Our results suggested that goblet cell hyperplasia and worm expulsion in G. seoi-infected mice should be induced by STAT6 signalling, in which IL-13 may be involved as a dominant triggering cytokine.

#Gymnophalloides seoi #intestinal trematode #goblet cell hyperplasia #worm expulsion #IL-13 #STAT6

참고문헌 (20)

참고문헌 신청

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