지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 204 - 211 (8page)
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초록· 키워드
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This study investigated the protective effects of diallyl disulfide (DADS) against cyclophosphamide (CP)-induced testicular toxicity in male rats. DADS was gavaged to rats once daily for 3 days at 100 mg/kg/day. One hour after the final DADS treatment, the rats were given a single intraperitoneal dose of 150 mg/kg CP. All rats were killed and necropsied on day 56 after CP treatment. Parameters of testicular toxicity included reproductive organ weight, testicular sperm head count, epididymal sperm motility and morphology, epididymal index, and histopathologic examinations. The CP treatment caused a decrease in body weight, testicular sperm head count, epididymal sperm motility, and epididymal index. The histopathological examination revealed various morphological alterations, characterized by degeneration of spermatogonia/spermatocytes, vacuolization, and decreased number of spermatids/spermatocytes in the testis, and cell debris and mild oligospermia in the ductus epididymis. In contrast, DADS pretreatment effectively attenuated the testicular toxicity caused by CP, including decreased sperm head count, epididymal sperm motility, and epididymal index and increased histopathological alterations in the testis and epididymis. These results indicate that DADS attenuates testicular toxicity induced by CP in rats.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (50)
참고문헌 신청
1. [학술지(정기간행물)] - Sahin K / 2010 / Lycopene and chemotherapy toxicity / Nutr Cancer 62 (7) : 988 ~ 995
2. [학술지(정기간행물)] - Baumann F / 2001 / Cyclophosphamide and related anticancer drugs / J Chromatogr B Biomed Sci Appl 764 : 173 ~ 192
3. [학술지(정기간행물)] - Shanafelt TD / 2007 / Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia / Cancer 109 (11) : 2291 ~ 2298
4. [학술지(정기간행물)] - Uber WE / 2007 / Acute antibodymediated rejection following heart transplantation / Am J Transplant 7 (9) : 2064 ~ 2074
5. [학술지(정기간행물)] - Qureshi MS / 1972 / Cyclophosphamide therapy and sterility / Lancet 2 (7790) : 1290 ~ 1291
2. [학술지(정기간행물)] - Baumann F / 2001 / Cyclophosphamide and related anticancer drugs / J Chromatogr B Biomed Sci Appl 764 : 173 ~ 192
3. [학술지(정기간행물)] - Shanafelt TD / 2007 / Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia / Cancer 109 (11) : 2291 ~ 2298
4. [학술지(정기간행물)] - Uber WE / 2007 / Acute antibodymediated rejection following heart transplantation / Am J Transplant 7 (9) : 2064 ~ 2074
5. [학술지(정기간행물)] - Qureshi MS / 1972 / Cyclophosphamide therapy and sterility / Lancet 2 (7790) : 1290 ~ 1291
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UCI(KEPA) : I410-ECN-0101-2015-500-001079812