지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 279 - 283 (5page)
이용수
초록· 키워드
오류제보하기
Acanthopanax koreanum Nakai, a well known traditional herb grown in Jeju Island, South of Korea, has been used as a tonic and sedative agent, as well as in the treatment of diabetes and immune diseases. Mutagenicity of two lignans, syringaresinol and tortoside A isolated from A. koreanum, was assessed using Salmonella/microsome (Ames) test. Tester strains used were Salmonella typhimurium TA98, TA100, TA1535, and Escherichia coli WP2uvrA. The mutagenic activity was determined both in the absence or presence of S9 mixture. As a result, tortoside A did not cause any increase in the number of his+ revertants in S. typhimurium and E. coli WP2uvrA strains in the presence or absence of S9 mix, compared to the controls. Similarly, low concentrations of syringaresinol (750 and 1,500 μg/plate) did not show any mutagenic properties in all bacterial strains, in the presence or absence of S9 mixture. However, in the high concentration of syringaresinol (3,000 μg/plate), the number of revertants were increased in TA1535 strains, in the absence of S9 metabolic activation. Therefore, in vivo experiments such as comet assay are needed to further determine the genotoxic/carciogenic potential of syringaresinol isolated from A. koreanum.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (10)
참고문헌 신청
Won-Bong PARK / 2010 / Modulation of IL-12 and IFN-γ Secretions by Eleutheroside E, Tortoside A, and Syringaresinol from Acanthopanax koreanum Nakai / 응용약물학회지 18(2):211~218
Kim, K. N. / 2012 / Acanthoic acid induces cell apoptosis through activation of the p38 MAPK pathway in HL-60 human promyelocytic leukaemia / Food Chem. 135:2112~2117
Kang, O. H. / 2006 / Inhibition of trypsin-induced mast cell activation by acanthoic acid / J. Ethnopharmacol. 105:326~331
Jung, J. M. / 2013 / The effects of a standardized Acanthopanax koreanum extract on stress-induced behavioral alterations in mice / J. Ethnopharmacol. 148:826~834
Mashele, S. / 2011 / Evaluation of the antimutagenic and mutagenic properties of Asparagus laricinus / Medical Technology S. A 25:33~36
Kim, K. N. / 2012 / Acanthoic acid induces cell apoptosis through activation of the p38 MAPK pathway in HL-60 human promyelocytic leukaemia / Food Chem. 135:2112~2117
Kang, O. H. / 2006 / Inhibition of trypsin-induced mast cell activation by acanthoic acid / J. Ethnopharmacol. 105:326~331
Jung, J. M. / 2013 / The effects of a standardized Acanthopanax koreanum extract on stress-induced behavioral alterations in mice / J. Ethnopharmacol. 148:826~834
Mashele, S. / 2011 / Evaluation of the antimutagenic and mutagenic properties of Asparagus laricinus / Medical Technology S. A 25:33~36
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UCI(KEPA) : I410-ECN-0101-2015-510-001071789